Results 71 to 80 of about 257,990 (304)

PROTAC‐Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy

open access: yesAdvanced Science, Volume 13, Issue 61, 3 November 2026.
A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu   +4 more
wiley   +1 more source

The Landscape of Long Non‐Coding RNAs Provides Insights Into the Domestication and Improvement of Pear Fruit

open access: yesAdvanced Science, EarlyView.
This study reveals that long non‐coding RNAs represent important regulatory components underlying pear domestication and improvement. Integrative multi‐omics analyses identify selected lncRNAs associated with fruit traits, while functional validation uncovers a lignin‐related lncRNA, lncRNA‐pys, that promotes lignin accumulation.
Bobo Song   +9 more
wiley   +1 more source

La profilaxis pre-exposición (PrEp) en la infección por VIH: Un nuevo hito en una carrera de fondo

open access: yesGalicia Clínica
Dentro del manejo clínico de las personas que viven con el virus de la inmunodeficiencia humana (VIH) y de la prevención de la transmisión del mismo, que aún hoy supone un importante problema de salud pública, la profilaxis pre-exposición (PrEP ...
Emilio Manuel Paez Guillán   +1 more
doaj   +1 more source

Convergence of Plasmid‐Mediated tmexCD‐toprJ With Critical Resistance Genes Fuels Spread of Multidrug Resistant Bacteria

open access: yesAdvanced Science, EarlyView.
Global dissemination of tmexCD‐toprJ across bacterial hosts and ecological niches is accompanied by its convergence with blaKPC, blaNDM, and mcr on mobile plasmids. Recombination and acquisition of resistance modules generate distinct multidrug resistant plasmid architectures, facilitating the emergence and spread of high‐risk bacterial populations ...
Kaiwen Song   +9 more
wiley   +1 more source

prep‐IR [PDF]

open access: yes, 2019
PURPOSE: To develop a motion-corrected 3D flow-insensitive imaging approach interleaved T2 prepared-inversion recovery (iT2 prep-IR) for simultaneous lumen and wall visualization of the great thoracic vessels and cardiac structures.METHODS: A 3D flow ...
Giulia Ginami   +17 more
core   +1 more source

Priority area 10—A BCW analysis of ‘PrEP users stop using PrEP’.

open access: yes, 2023
Priority area 10—A BCW analysis of ‘PrEP users stop using PrEP’.
Dan Clutterbuck (17118236)   +10 more
core   +1 more source

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

open access: yesAdvanced Science, EarlyView.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen   +6 more
wiley   +1 more source

A picture of Saint Peter's Prep taken from the side of Grand Street.

open access: yes, 2007
Founded in 1872 by the Jesuits, Saint Peter's Preparatory School (also known as Saint Peter's Prep or simply Prep) is an independent, preparatory, and all-male day school located in Jersey City.
Beards, Daniel E.
core   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

open access: yesAdvanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu   +10 more
wiley   +1 more source

Postdoc prep [PDF]

open access: yesNature, 2006
Jabbar, Bennett, Cherie, Butts
openaire   +2 more sources

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