Results 81 to 90 of about 257,990 (304)

OsCPK12‐OsATPD1 Module Regulates Photosynthetic Acclimation to Light Stress in Rice

Advanced Science, EarlyView.
OsCPK12 interacts and phosphorylates OsAtpD1 at Ser8 in its transit peptide. This phosphorylation promote its chloroplast translocation, thereby maintaining ATP synthase activity and proton gradient (ΔpH) homeostasis and regulating photosynthetic acclimation, photoprotection, and repair under light stress.
Beifang Wang, Aaron Chan, Yongyi Fan, Yanwu Wang, Pao Xue, Yingxin Zhang, Xiaodeng Zhan, Weixun Wu, Ping Yu, Daibo Chen, Junlin Fu, Yongbo Hong, Xihong Shen, Lianping Sun, Aike Zhu, Shihua Cheng, Qunen Liu, Liyong Cao   +17 more
wiley   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Targets to Increase HIV Pre-Exposure Prophylaxis (PrEP) Uptake Among Communities in Northeast Georgia

Journal of the Georgia Public Health Association
Background: This study seeks to identify targets to increase HIV pre-exposure prophylaxis (PrEP) uptake in Athens-Clarke County, GA, a non-urban area with high HIV burden and poor PrEP utilization.
Kaley E Parchinski, Molly Hirsh, Andrew Cheng, Nia Kalifa, Manvi Manyam   +4 more
doaj   +1 more source

A research alliance

Medicine Anthropology Theory, 2017
This article explores a research alliance across fields and continents in the wake of the early and controversial HIV-prevention clinical trials of pre-exposure prophylaxis (PrEP).
Kristin Peterson, Morenike Folayan
doaj   +1 more source

Variables associated to PrEP awareness, use or willingness to use PrEP, and need of PrEP for MSM living in Spain.

, 2018
Variables associated to PrEP awareness, use or willingness to use PrEP, and need of PrEP for MSM living in Spain.
Ferran Pujol (5873681), María José Fuster-Ruiz de Apocada (5873684), Jorge del Romero (247501), Débora Álvarez-del Arco (5873666), Santiago Moreno (90184), Jorge Garrido (2132347), Michael Meulbroek (5873678), Carlos Iniesta (5873663), Asunción Díaz (4112470), Pep Coll (5873687), Nieves Sanz (5873675), Belén Alejos (5873672), Melchor Riera (5526905), Luis Miguel García-Sousa (5873669), Oskar Ayerdi (5873690), Julia del Amo (148920), Antonio Antela (2624800), Juanse Hernández (5873693)   +17 more
core   +1 more source

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

Advanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao, Guoling Li, Yinghui Wei, Zhen Gu   +12 more
wiley   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Accès à la prophylaxie préexposition (PrEP) en Afrique de l’Ouest : nouvelles questions et enjeux

, 2016
International audienceAu cours de la dernière décennie, le champ de la prévention de la transmission sexuelle du VIH a connu des évolutions majeures, notamment en raison du développement de nouveaux outils biomédicaux : circoncision masculine, traitement
Larmarange, Joseph
core   +1 more source

Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants

Advanced Science, EarlyView.
Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Sarah Stainer, Rong Zhu, Manuel Reithofer, Gerhard Stadlmayr, Katharina Stadlbauer, Panchika Prangkio, Christoph Rippel, Markus Hahn, Aniko Eva Kasztner, Stefanie Stohl, Petr Bednar, Daniel Ruzek, David Glück, Robert Tampé, Gordana Wozniak‐Knopp, Yoo Jin Oh, Miriam Klausberger, Peter Hinterdorfer   +17 more
wiley   +1 more source

[Folder 01]: PrEP 1519

O PrEP 1519 é um projeto de pesquisa que tem como objetivo a prevenção do HIV/AIDS entre adolescentes de 15 a 19 ...
Projeto PrEP 1519
core