Results 21 to 30 of about 209,419 (263)

La profilaxis pre-exposición (PrEp) en la infección por VIH: Un nuevo hito en una carrera de fondo

Galicia Clínica
Dentro del manejo clínico de las personas que viven con el virus de la inmunodeficiencia humana (VIH) y de la prevención de la transmisión del mismo, que aún hoy supone un importante problema de salud pública, la profilaxis pre-exposición (PrEP ...
Emilio Manuel Paez Guillán, Alba García Villafranca   +1 more
doaj   +1 more source

The paradoxes of PrEP: rejection, reluctancy, and novel gay identities in biomedical HIV prevention in Serbia

InterAlia, 2021
This article explores the different ways in which gay men in Serbia perceive PrEP as a novel method of HIV prevention. In the article, I draw on data from my research on PrEP use among thirty gay men in Belgrade. The use of PrEP is still very low amongst
Zoran Milosavljević
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Trust in physicians among young sexual minority men [PDF]

Journal of Men's Health
Trust in physicians and the medical establishment more broadly is critical for access to and provision of relevant healthcare services. This is especially true for sexual minority men (SMM) as their healthcare is negatively impacted due to stigma and ...
Yifan Lai, Madeline Cohodes, Marybec Griffin, Tejossy John, Benjamin Grin, Perry N. Halkitis, Jessica Jaiswal   +6 more
doaj   +1 more source

HIV prevention clinical trials’ community engagement guidelines: inequality, and ethical conflicts

Global Bioethics, 2020
In 2004 and 2005, the first clinical trials were launched to investigate the use of tenofovir for HIV prevention in Cambodia, Cameroon, Nigeria and Thailand. Controversies erupted over the ethical integrity of the research protocol.
Morenike O. Folayan, Kristin Peterson
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Targets to Increase HIV Pre-Exposure Prophylaxis (PrEP) Uptake Among Communities in Northeast Georgia

Journal of the Georgia Public Health Association
Background: This study seeks to identify targets to increase HIV pre-exposure prophylaxis (PrEP) uptake in Athens-Clarke County, GA, a non-urban area with high HIV burden and poor PrEP utilization. Methods: A cross sectional survey of adults attending
Kaley E. Parchinski, Molly Hirsh, Andrew Cheng, Nia Kalifa, Manvi Manyam   +4 more
doaj   +1 more source

COVID-19 crisis effect on HIV service delivery in Egypt: Hard times or blessings in disguise?

Southern African Journal of HIV Medicine, 2020
No abstract available.
Rahma Mohamed, Heba Wanis, Sonia Zebachi, Menna-t-allah El-Kotamy, Gamal Esmat, Ahmed Cordie   +5 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source