Results 71 to 80 of about 498,894 (298)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Live-Cell Imaging of Single Receptor Composition Using Zero-Mode Waveguide Nanostructures [PDF]

, 2012
We exploit the optical and spatial features of subwavelength nanostructures to examine individual receptors on the plasma membrane of living cells. Receptors were sequestered in portions of the membrane projected into zero-mode waveguides.
Dougherty, Dennis A., Korlach, Jonas, Lester, Henry A., Luong, Khai, Richards, Christopher I., Srinivasan, Rahul, Turner, Stephen W.   +6 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Advancements of Novel Processing Technology in Prepared Dishes Industry

Shipin gongye ke-ji
In recent years, prepared dishes entered millions of households, and the market size was continuously expanding. Traditional processing of prepared dishes mainly relies on thermal methods such as high-temperature cooking and high-temperature ...
Shiting SU, Xiaopeng LIU, Fang CHEN, Li DONG, Xiaosong HU   +4 more
doaj   +1 more source

Effects of terrigenous sediment on settlement and survival of the reef coral Pocillopora damicornis [PDF]

PeerJ, 2014
Survival and settlement of Pocillopora damicornis larvae on hard surfaces covered with fine (
Kaipo Perez III, Kuʻulei S. Rodgers, Paul L. Jokiel, Claire V. Lager, Daniel J. Lager   +4 more
doaj   +2 more sources

Transplantation of Cultivated Oral Mucosal Epithelium Prepared in Fibrin-Coated Culture Dishes

Investigative Opthalmology & Visual Science, 2012
To compare the clinical results of cultivated oral mucosal epithelial cell sheet transplantation (COMET) of substrate-free sheets with those of COMET of amniotic membrane (AM)-based sheets.Sixteen eyes receiving COMET of substrate-free sheets (substrate-free group) were studied retrospectively and compared with disease-, age-, and ocular surface status-
Masatoshi, Hirayama, Yoshiyuki, Satake, Kazunari, Higa, Takefumi, Yamaguchi, Jun, Shimazaki   +4 more
openaire   +2 more sources

Cured Meats in Ancient and Byzantine Sources: Ham, Bacon and Tuccetum [PDF]

, 2014
The present study discusses the role of salt-cured meat in dietetics, medicine and gastronomy demonstrated mainly in ancient and Byzantine medical (Galen, Oribasius, Aetius of Amida, Anthimus, Alexander of Tralles and Paul of Aegina) and agronomic ...
Jagusiak, Krzysztof, Kokoszko, Maciej, Rzeźnicka, Zofia   +2 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

From controversy to consensus: how consumers and policy interactions shape prepared dishes and food discourse in China

Frontiers in Sustainable Food Systems
China’s prepared dishes industry has experienced rapid development and is undergoing a transformative shift from industrialized production to public recognition and acceptance.
Huidan Xue, Ziling He, Qiai Wang, Wen-Hao Su   +3 more
doaj   +1 more source

Research on the Pre-prepared Food Industry Based on Case Studies [PDF]

BIO Web of Conferences
With the global food consumption pattern changing to convenient and healthy, prepared food has gradually become an emerging food industry. In recent years, due to the new crown epidemic, China’s prepared food industry has developed greatly, and the ...
Wang Yizheng, Li Qing, He Ziling, Liu Zihan   +3 more
doaj   +1 more source