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Behavioural Brain Research, 2023
Prepulse inhibition (PPI) is a reduction of the acoustic startle reflex (ASR) when the startling stimulus is preceded by a weaker and non-startling stimulus (i.e., prepulse). Previous studies have revealed that PPI can be top-down modulated by selective attention to the fear-conditioned prepulse in animals.
Xiaoqin Yang +5 more
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Prepulse inhibition (PPI) is a reduction of the acoustic startle reflex (ASR) when the startling stimulus is preceded by a weaker and non-startling stimulus (i.e., prepulse). Previous studies have revealed that PPI can be top-down modulated by selective attention to the fear-conditioned prepulse in animals.
Xiaoqin Yang +5 more
openaire +2 more sources
Prepulse inhibition following lesions of the inferior colliculus: prepulse intensity functions
Physiology and Behavior, 1998The magnitude of the acoustic startle response can be reduced by a relatively weak sound presented immediately before the startle-eliciting sound; this phenomenon has been termed prepulse inhibition (PPI). Previous studies reported that PPI was present in the decerebrate rat, indicating that the primary neural pathways mediating PPI are located in the ...
R J Beninger
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Enhanced prepulse inhibition of startle using salient prepulses in rats
International Journal of Psychophysiology, 2006Prepulse inhibition (PPI) of the startle reflex occurs when a non-startling stimulus is presented shortly prior to the startling stimulus. PPI is an operational measure for sensorimotor gating. PPI in humans is enhanced by attention, but there is no evidence yet for attentional modulation of PPI in animals.
Stephan, Röskam, Michael, Koch
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Prepulse inhibition deficits in women with PTSD
Psychophysiology, 2016AbstractPrepulse inhibition (PPI) is an automatic and preattentive process, whereby a weak stimulus attenuates responding to a sudden and intense startle stimulus. PPI is a measure of sensorimotor filtering, which is conceptualized as a mechanism that facilitates processing of an initial stimulus and is protective from interruption by a later response.
Suzanne L, Pineles +7 more
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Prepulse inhibition in patients with Alzheimer’s disease
Neurobiology of Aging, 2004Prepulse inhibition (PPI) is used as a measure for sensorimotor gating. Studies in animals have indicated that hippocampus and entorhinal cortex, structures which are affected in mild Alzheimer's disease (AD), are involved in the regulation of PPI. The objectives of this study were to determine if patients with very mild AD had altered PPI, and to ...
Anne-Mette, Hejl +4 more
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Acoustic Startle Reflex and Prepulse Inhibition
Current Protocols in Mouse Biology, 2012AbstractThe completion of genome sequencing in humans and mice has opened new opportunities to study the relationship between gene expression and behavior and for development of novel therapeutic approaches for brain diseases. Recently, several international programs for large‐scale production and phenotyping of genetically modified mice have been ...
Abdel Mottalib, Ouagazzal +1 more
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The relationship between prepulse detection and prepulse inhibition of the acoustic startle reflex
Psychophysiology, 2001Prepulse inhibition (PPI) of the startle reflex is defined as the attenuation of the startle response to a startling stimulus (pulse), when such a stimulus is briefly preceded by a stimulus of subthreshold intensity (prepulse). PPI is thought to be neither learned nor due to conscious response inhibition, as it occurs at stimulus onset asynchronies ...
Postma, P +3 more
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Role of dopamine in prepulse inhibition of acoustic startle
Psychopharmacology, 2000Prepulse inhibition of acoustic startle is the reduction in startle response to an intense auditory stimulus when this stimulus is immediately preceded by a weaker prestimulus. Prepulse inhibition occurs normally in humans and experimental animals, but schizophrenic persons often exhibit a marked impairment in this measure.
Engel J A, Svensson L
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Testing Prepulse Inhibition of Acoustic Startle in Rodents
2023Prepulse inhibition (PPI) is a measure of sensorimotor gating which is widely used in rodents to study information processing and attention dysfunction. PPI is commonly measured in rats and mice using automated equipment. Here, we present details of a PPI testing protocol extensively used in previous studies.
Maarten, van den Buuse, Emily J, Jaehne
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Pharmacology Biochemistry and Behavior, 2007
Prepulse inhibition (PPI) of the auditory startle response (ASR) is a behavioral test that has been used to measure auditory thresholds, to assess sensory-motor integration functions, and its use has been recommended in the United States Environmental Protection Agency Developmental Neurotoxicity Guideline (OPPTS 870.6300).
Amanda K, Andrus +4 more
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Prepulse inhibition (PPI) of the auditory startle response (ASR) is a behavioral test that has been used to measure auditory thresholds, to assess sensory-motor integration functions, and its use has been recommended in the United States Environmental Protection Agency Developmental Neurotoxicity Guideline (OPPTS 870.6300).
Amanda K, Andrus +4 more
openaire +2 more sources