Results 211 to 220 of about 4,510,822 (391)

Rupestonic Acid of Artemisia Rupestris L. Extract Treats Pulmonary Fibrosis in COPD by Targeting TGF‐β1

open access: yesAdvanced Science, EarlyView.
RA of EEAR inhibits TGF‐β1 ubiquitination and changes conformation by target binding TGF‐β1, regulating TGF‐β1/Smad2/3 signaling pathway. Thus it down‐regulated downstream protein expression, inhibited EMT and collagen deposition of ECM, in order to EEAR preventing PF in COPD.
Lingfeng Peng   +6 more
wiley   +1 more source

From Prescription Drugs to Natural Health Products: Medication Use in Canadian Infants. [PDF]

open access: yesChildren (Basel), 2022
Bedard P   +11 more
europepmc   +1 more source

Parallel Imports and Mandatory Substitution Reform - A Kick or A Muff for Price Competition in Pharmaceuticals? [PDF]

open access: yes
What has been the effect of competition from parallel imports on prices of locally-sourced on-patent drugs? Did the 2002 Swedish mandatory substitution reform increase this competition?
Granlund, David, Köksal , Miyase Yesim
core   +1 more source

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

open access: yesAdvanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu   +9 more
wiley   +1 more source

Association Between Nonmedical Use of Prescription Drugs and Suicidal Behavior Among Adolescents.

open access: yesJAMA pediatrics, 2016
Lan Guo   +9 more
semanticscholar   +1 more source

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

open access: yesAdvanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen   +8 more
wiley   +1 more source

Patterns of Manufacturer Coupon Use for Prescription Drugs in the US, 2017-2019.

open access: yesJAMA Netw Open, 2023
Kang SY   +3 more
europepmc   +1 more source

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