Results 41 to 50 of about 722,059 (308)

Qinggan Yipi capsule ameliorates hepatic fibrosis in rats by down-regulating the TGF-β1/Smad2/3 signaling pathway and improving gut microbiota imbalance

Frontiers in Pharmacology
Background and objectiveQinggan Yipi Capsule (QgYp) is a hospital preparation that has been used for many years in the treatment of chronic liver diseases. However, the mechanism of QgYp in ameliorating hepatic fibrosis (HF) remains unclear.
Wenjing Xue, Haiqing Liu, Ziheng Su, Siqi Wang, Junping Cheng, Yunzhi Pan, Lurong Zhang   +6 more
doaj   +1 more source

The influence of hospitalisation on the initiation, continuation and discontinuation of benzodiazepines and Z-drugs – an observational study

Swiss Medical Weekly, 2018
BACKGROUND AND OBJECTIVES Hospitalisation influences drug therapy in ambulatory care and this influence is generally negatively perceived. The few studies that have explored changes in benzodiazepine or sleep medication use as a function of ...
Thomas Grimmsmann, Markus Harden, Thomas Fiß, Wolfgang Himmel   +3 more
doaj   +1 more source

The Pauli principle in a three-body cluster model and the momentum distributions after fragmentation of 6He and 11Li [PDF]

, 1996
We investigate two simple prescriptions to account for the Pauli principle in a three-body cluster model employing a new method based on an adiabatic hyperspherical expansion to solve the Faddeev equations in coordinate space.
A.S. Jensen, Abramovich, Ajzenberg-Selove, Al-khalili, Bang, Baye, D.V. Fedorov, E. Garrido, Esbensen, Fedorov, Fedorov, Fedorov, Fedorov, Feshbach, Fiedeldey, Friedman, Garrido, Goldberger, Hansen, Hansen, Hohlen, Humbert, Johannsen, Kobayashi, Kobayashi, Kobayashi, Korsheninnikov, Kukulin, Marsh, Migdal, Nilsson, Richard, Thompson, Utsunomiya, Young, Zhukov, Zinser   +36 more
core   +2 more sources

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Influence of practice location on prescribing, diabetes care, and colorectal cancer screening among Czech general practitioners during the COVID-19 pandemic [PDF]

Epidemiology and Health
OBJECTIVES The provision of primary health care was not interrupted during the coronavirus disease 2019 (COVID-19) pandemic in Czechia, although the capacity and resources of providers changed.
Jan Bělobrádek, Luděk Šídlo, Tom Philipp   +2 more
doaj   +1 more source

Patterns of Tumor Necrosis Factor Inhibitor (TNFi) Biosimilar Use Across United States Rheumatology Practices. [PDF]

, 2020
ObjectiveIt is unclear if biosimilars of biologics for inflammatory arthritis are realizing their promise to increase competition and improve accessibility.
Bansback, Nick, Curtis, Jeffrey R, Evans, Michael, He, Zeling, Huang, Jie, Johansson, Tracy, Liao, Katherine P, Michaud, Kaleb, Schmajuk, Gabriela   +8 more
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

TMF Attenuates Cognitive Impairment and Neuroinflammation by Inhibiting the MAPK/NF-κB Pathway in Alzheimer’s Disease: A Multi-Omics Analysis

Marine Drugs
The rising prevalence of Alzheimer’s disease (AD) underscores the urgent need for novel therapeutic agents derived from natural sources. Among flavonoids, 3′,4′,5,7-tetramethoxyflavone (TMF), a structural analog of luteolin, has gained attention for its ...
Yonglin Liu, Xi Xu, Xiaoming Wu, Guodong Yang, Jiaxin Luo, Xinli Liang, Jie Chen, Yiguang Li   +7 more
doaj   +1 more source

Implementing evidence‐based anticoagulant prescribing: User‐centered design findings and recommendations

Research and Practice in Thrombosis and Haemostasis, 2022
Background Direct oral anticoagulants (DOACs) are widely used medications with an unacceptably high rate of prescription errors and are a leading cause of adverse drug events.
F. Jacob Seagull, Michael S. Lanham, Michelle Pomorski, Mollie Callahan, Elizabeth K. Jones, Geoffrey D. Barnes   +5 more
doaj   +1 more source

Energy Distribution associated with Static Axisymmetric Solutions [PDF]

, 2006
This paper has been addressed to a very old but burning problem of energy in General Relativity. We evaluate energy and momentum densities for the static and axisymmetric solutions. This specializes to two metrics, i.e., Erez-Rosen and the gamma metrics,
A. Komar, A. Trautman, C. Möller, C. Möoller, C.C. Chang, C.W. Misner, F. Esposito, F.I. Cooperstock, H. Weyl, H.E.J. Curzon, J.D. Brown, J.M. Aguirregabiria, K.S. Virbhadra, K.S. Virbhadra, K.S. Virbhadra, K.S. Virbhadra, M. Sharif, M. Sharif, M. Sharif, M. Sharif, M. Sharif, N. Rosen, P.G. Bergman, R. C. Tolman, R. Penrose, R.M. Gad, R.M. Gad, S. Weinberg, S.A. Hayward, S.S. Xulu, S.S. Xulu, T. Bringley, Tasnim Fatima   +32 more
core   +2 more sources