Results 51 to 60 of about 24,368 (229)

Presenilins Upregulate Functional K+Channel Currents in Mammalian Cells

Neurobiology of Disease, 1998
Mutations in presenilin 1 (PS-1) and presenilin 2 (PS-2) have been linked to early onset, autosomal dominant Alzheimer's disease. Neither the normal function(s) of the presenilins nor their role(s) in mediating the devastating neurological and ...
Sacha A. Malin, W.-X.Athena Guo, Gita Jafari, Alison M. Goate, Jeanne M. Nerbonne   +4 more
doaj   +1 more source

Presenilin-1 Dependent Neurogenesis Regulates Hippocampal Learning and Memory. [PDF]

PLoS ONE, 2015
Presenilin-1 (PS1), the catalytic core of the aspartyl protease γ-secretase, regulates adult neurogenesis. However, it is not clear whether the role of neurogenesis in hippocampal learning and memory is PS1-dependent, or whether PS1 loss of function in ...
Jacqueline A Bonds, Yafit Kuttner-Hirshler, Nancy Bartolotti, Matthew K Tobin, Michael Pizzi, Robert Marr, Orly Lazarov   +6 more
doaj   +1 more source

Glycogen synthase kinase 3β (GSK3β) and presenilin (PS) are key regulators of kinesin-1-mediated cargo motility within axons

Frontiers in Cell and Developmental Biology, 2023
It has been a quarter century since the discovery that molecular motors are phosphorylated, but fundamental questions still remain as to how specific kinases contribute to particular motor functions, particularly in vivo, and to what extent these ...
Rupkatha Banerjee, Shermali Gunawardena
doaj   +1 more source

Calcium Signaling and Mitochondrial Function in Presenilin 2 Knock-Out Mice: Looking for Any Loss-of-Function Phenotype Related to Alzheimer’s Disease

Cells, 2021
Alzheimer′s disease (AD) is the most common age-related neurodegenerative disorder in which learning, memory and cognitive functions decline progressively.
Alice Rossi, Luisa Galla, Chiara Gomiero, Lorena Zentilin, Mauro Giacca, Valentina Giorgio, Tito Calì, Tullio Pozzan, Elisa Greotti, Paola Pizzo   +9 more
doaj   +1 more source

Evidence for phosphorylation and oligomeric assembly of presenilin 1 [PDF]

Proceedings of the National Academy of Sciences, 1997
Pathogenic mutations in presenilin 1 (PS1) are associated with ≈50% of early-onset familial Alzheimer disease. PS1 is endoproteolytically cleaved to yield a 30-kDa N-terminal fragment (NTF) and an 18-kDa C-terminal fragment (CTF). Using COS7 cells transfected with human PS1, we have found that phorbol 12,13-dibutyrate and forskolin increase the state ...
M, Seeger, C, Nordstedt, S, Petanceska, D M, Kovacs, G K, Gouras, S, Hahne, P, Fraser, L, Levesque, A J, Czernik, P S, George-Hyslop, S S, Sisodia, G, Thinakaran, R E, Tanzi, P, Greengard, S, Gandy   +14 more
openaire   +2 more sources

A Pathogenic Presenilin-1 Val96Phe Mutation from a Malaysian Family

Brain Sciences, 2021
Presenilin-1 (PSEN1) is one of the causative genes for early onset Alzheimer’s disease (EOAD). Recently, emerging studies have reported several novel PSEN1 mutations among Asians.
Eva Bagyinszky, Gaik-Siew Ch’ng, Mei-Yan Chan, Seong Soo A. An, SangYun Kim   +4 more
doaj   +1 more source

Intracellular trafficking of TREM2 is regulated by presenilin 1 [PDF]

Experimental & Molecular Medicine, 2017
Genetic mutations in triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to a variety of neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, frontotemporal dementia and Parkinson's disease. In the brain, TREM2 is highly expressed on the cell surface of microglia, where it can transduce signals ...
Zhao, Yingjun, Li, Xiaoguang, Huang, Timothy, Jiang, Lu-Lin, Tan, Zhenqiu, Zhang, Muxian, Cheng, Irene Han-Juo, Wang, Xin, Bu, Guojun, Zhang, Yun-Wu, Wang, Qi, Xu, Huaxi   +11 more
openaire   +3 more sources

Chromosome Missegregation and Trisomy 21 Mosaicism in Alzheimer's Disease

Neurobiology of Disease, 1999
A connection between Alzheimer's disease (AD) and Down syndrome (trisomy 21) is indicated by the fact that all Down syndrome individuals develop Alzheimer's disease neuropathology by the 4th decade of life. Previous studies have examined the frequency of
Lisa N. Geller, Huntington Potter
doaj   +1 more source

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

Direct association of presenilin‐1 with β‐catenin

FEBS Letters, 1998
Families bearing mutations in the presenilin‐1 (PS1) gene develop Alzheimer's disease (AD). However, the mechanism through which PS1 causes AD is unclear. The co‐immunoprecipitation with PS1 in transfected COS‐7 cells indicates that PS1 directly interacts with endogenous β‐catenin, and the interaction requires residues 322–450 of PS1 and 445–676 of β ...
Murayama, Miyuki, Tanaka, Shoji, Palacino, James, Murayama, Ohoshi, Honda, Toshiyuki, Sun, Xiaoyan, Yasutake, Kaori, Nihonmatsu, Naomi, Wolozin, Benjamin, Takashima, Akihiko   +9 more
openaire   +2 more sources