Results 31 to 40 of about 35,583 (221)
Presenilin 1 is essential for cardiac morphogenesis [PDF]
Developmental Dynamics, 2004 AbstractPresenilin 1 (PS1) is the gene responsible for the development of early‐onset familial Alzheimer's disease. PS1‐deficient mice have been reported to show defects in neurogenesis, somitogenesis and angiogenesis. Here, we report cardiac anomaly in PS1‐deficient mice: the mutant hearts exhibited ventricular septal defect, double outlet right ...
Mitsunari, Nakajima +3 more
openaire +2 more sources
Presenilin-1 and Memories of the Forebrain [PDF]
Neuron, 2001 In this issue of Neuron, report that forebrain-specific Presenilin-1 conditional knockout mice show defects in enrichment-induced neurogenesis in the dentate gyrus. This defect in neurogenesis is associated with enhanced fear memory of contextual cues when animals are subjected to enrichment between training and testing.
McGuire, Sean E, Davis, Ronald L
openaire +2 more sources
The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease [PDF]
, 2015 Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main
Baillie, George S. +3 more
core +1 more source
Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator. [PDF]
, 2015 BackgroundAmyloid-β (Aβ) 42 has been implicated as the initiating molecule in the pathogenesis of Alzheimer's disease (AD); thus, therapeutic strategies that target Aβ42 are of great interest.
Akula, Rajender +14 more
core +3 more sources
Fatty acids increase presenilin-1 levels and γ-secretase activity in PSwt-1 cells
Journal of Lipid Research, 2004 Presenilin-1 (PS1) is an important determinant of the γ-secretase activity necessary for the generation of β-amyloid (Aβ), likely the central pathogenic molecule in Alzheimer's disease.
Yanzhu Liu +5 more
doaj +1 more source
Presenilin promotes dietary copper uptake. [PDF]
PLoS ONE, 2013 Dietary copper is essential for multicellular organisms. Copper is redox active and required as a cofactor for enzymes such as the antioxidant Superoxide Dismutase 1 (SOD1). Copper dyshomeostasis has been implicated in Alzheimer's disease.
Adam Southon +5 more
doaj +1 more source
ApoER2 processing by presenilin‐1 modulates reelin expression [PDF]
The FASEB Journal, 2013 The reelin signaling protein and its downstream components have been associated with synaptic plasticity and neurotransmission. The reelin signaling pathway begins with the binding of reelin to the transmembrane lipoprotein receptor apolipopro‐tein E receptor 2 (ApoER2), which in turns induces the sequential cleavage of ApoER2 by ...
Balmaceda V +7 more
openaire +6 more sources
Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report. [PDF]
, 2019 We identified a PSEN1 (presenilin 1) mutation carrier from the world's largest autosomal dominant Alzheimer's disease kindred, who did not develop mild cognitive impairment until her seventies, three decades after the expected age of clinical onset.
A Butler +79 more
core +3 more sources
Switched Aβ43 generation in familial Alzheimer’s disease with presenilin 1 mutation
Translational Psychiatry, 2021 Presenilin (PS) with a genetic mutation generates abundant β-amyloid protein (Aβ) 43. Senile plaques are formed by Aβ43 in the cerebral parenchyma together with Aβ42 at middle ages. These brains cause the early onset of Alzheimer’s disease (AD), which is
Nobuto Kakuda +5 more
doaj +1 more source
Functions of p120ctn in development and disease [PDF]
, 2012 p120 catenin (p120ctn), a component of the cadherin-catenin complex, was the first member to be identified in a most interesting subfamily of the Armadillo family. Several p120ctn isoforms are generated by alternative splicing.
Pieters, Tim +2 more
core +1 more source