Role of Oxidative Stress Markers F2-Isoprostanes and Presenilin-1 in Clinical Diagnosed Alzheimer’s Diseases [PDF]
Journal of Pharmacy and Bioallied SciencesIntroduction: Alzheimer’s disease (AD), a neurodegenerative disorder closely associated with aging, is characterized by progressive cognitive decline and is a leading cause of dementia worldwide.
Dilip Raj Timalsina +2 more
doaj +5 more sources
Presenilin 1 Modulates Acetylcholinesterase Trafficking and Maturation. [PDF]
Int J Mol Sci, 2023 In Alzheimer’s disease (AD), the reduction in acetylcholinesterase (AChE) enzymatic activity is not paralleled with changes in its protein levels, suggesting the presence of a considerable enzymatically inactive pool in the brain. In the present study, we validated previous findings, and, since inactive forms could result from post-translational ...
Cortés-Gómez MÁ +4 more
europepmc +6 more sources
Presenilin 1 deficiency impairs Aβ42-to-Aβ40- and angiotensin-converting activities of ACE [PDF]
Frontiers in Aging Neuroscience, 2023 IntroductionAlzheimer’s disease (AD) is associated with amyloid β-protein 1-42 (Aβ42) accumulation in the brain. Aβ42 and Aβ40 are the major two species generated from amyloid precursor protein.
Yuan Gao +6 more
doaj +2 more sources
EMBO Molecular Medicine, 2016 As stated by the prevailing amyloid cascade hypothesis, Alzheimer's disease (AD) is caused by the aggregation and cerebral deposition of long amyloid‐β peptide (Aβ) species, which are released from a C‐terminal amyloid precursor protein fragment by γ ...
Johannes Trambauer +2 more
exaly +2 more sources
Role of Presenilin-1 in Aggressive Human Melanoma. [PDF]
Int J Mol Sci, 2022 Presenilin-1 (PS-1), a component of the gamma (γ)-secretase catalytic complex, has been implicated in Alzheimer’s disease (AD) and in tumorigenesis. Interestingly, AD risk is inversely related to melanoma, suggesting that AD-related factors, such as PS-1, may affect melanomagenesis. PS-1 has been shown to reduce Wnt activity by promoting degradation of
Sidor J +4 more
europepmc +3 more sources
High-intensity interval training combined with cannabidiol supplementation improves cognitive impairment by regulating the expression of apolipoprotein E, presenilin-1, and glutamate proteins in a rat model of amyloid β-induced Alzheimer’s disease [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Alzheimer’s disease (AD) is a major public concern and one of the primary types of dementia characterized by memory impairment and cognitive decline.
Mohamad Reza Kordi +7 more
doaj +2 more sources
A Review Article on Oxidative Stress Markers F2-Isoprostanes and Presenilin-1 in Alzheimer’s Disease
Journal of Pharmacy and Bioallied SciencesAmyloid-beta plaque and tau tangle buildup lead to Alzheimer’s disease (AD), a brain disorder that causes ongoing mental decline. More and more studies show that oxidative stress plays a crucial role in how AD develops and progresses. This review focuses
Dilip Raj Timalsina +2 more
doaj +2 more sources
Increasing expression of presenilin 1, β-catenin, and p-PTEN and its regulatory roles on cell invasion in gastric cancer. [PDF]
World J Gastrointest OncolLin X, Lin GF, Gu FT, Li YL.
europepmc +2 more sources
Effects of presenilin-1 familial Alzheimer’s disease mutations on γ-secretase activation for cleavage of amyloid precursor protein [PDF]
Communications Biology, 2023 Gaussian accelerated molecular dynamics (GaMD) simulations and biochemical experiments in E.Coli provide mechanistic insight into how Presenilin-1 familial Alzheimer’s disease mutations affect structural dynamics and enzyme-substrate interactions of γ ...
Hung N. Do +4 more
doaj +2 more sources