Results 1 to 10 of about 24,368 (229)

P3–399: The interleukin–1 type–1 receptor is a substrate for presenilin–dependent gamma–secretase cleavage [PDF]

, 2006
Baukje M. Elzinga, Justin V. McCarthy
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Mutant Presenilin 1 Increases the Expression and Activity of BACE1 [PDF]

, 2009
Luca Giliberto, Roberta Borghi, Alessandra Piccini, Rosa Mangerini, Sandro Sorbi, Gabriella Cirmena, Anna Garuti, Bernardino Ghetti, Fabrizio Tagliavini, Mohamed R. Mughal, Mark P. Mattson, Xiongwei Zhu, Xinglong Wang, Michela Guglielmotto, Elena Tamagno, Massimo Tabaton   +15 more
openalex   +1 more source

A Role for Presenilin-1 in Nuclear Accumulation of Ire1 Fragments and Induction of the Mammalian Unfolded Protein Response [PDF]

, 1999
Maho Niwa, Carmela Sidrauski, Randal J. Kaufman, Peter Walter   +3 more
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Mutations in presenilin 2 and its implications in Alzheimer’s disease and other dementia-associated disorders

Clinical Interventions in Aging, 2015
Yan Cai,1 Seong Soo A An,1 SangYun Kim2 1Department of Bionano Technology, Gachon Medical Research Institute, Gachon University, 2Department of Neurology, Seoul National University College of Medicine, Seoul National University Bundang Hospital ...
Cai Y, An SSA, Kim SY
doaj  

Familial Frontotemporal Dementia-Associated Presenilin-1 c.548G>T Mutation Causes Decreased mRNA Expression and Reduced Presenilin Function in Knock-In Mice [PDF]

, 2012
Hirotaka Watanabe, Dan Xia, Takahisa Kanekiyo, Raymond J. Kelleher, Jie Shen   +4 more
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Uncoupled Packaging of Amyloid Precursor Protein and Presenilin 1 into Coat Protein Complex II Vesicles [PDF]

, 2004
Jin Oh Kim, Susan Hamamoto, Mariella Ravazzola, Lelio Orci, Randy Schekman   +4 more
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Identify the Binding Interface between Calsenilin and Presenilin 1 C-Terminal Fragment [PDF]

, 2015
Khoa Pham, Jaroslava Mikšovská
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Generation of human induced pluripotent stem cell line from a familial Alzheimer’s disease patient carrying missense mutations in PSEN1 and MAPT genes

Stem Cell Research
Alzheimer’s disease (AD), pathologically characterized by misfolding and accumulation of amyloid beta (Aβ) and hyperphosphorylated tau, is the leading cause of neurodegenerative dementia, accounting for 60–80 % of cases. The familial form of AD is caused
Ashaq H. Najar, Sofia E. Sepulveda, Camila Gherardelli, Fatemeh Elahian, Amber Fontenot-Roberts, Aleksandar Bajic, David H. Hunter, Claudio Soto, Paul E. Schulz, Abhisek Mukherjee   +9 more
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Presenilin 1 transgene addition to amyloid precursor protein overexpressing transgenic rats increases amyloid beta 42 levels and results in loss of memory retention [PDF]

, 2016
Cansu Agca, Diana Klakotskaia, Todd R. Schachtman, Anthony W.S. Chan, James J. Lah, Yuksel Agca   +5 more
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C-Terminal Maturation Fragments of Presenilin 1 and 2 Control Secretion of APPα and Aβ by Human Cells and Are Degraded by Proteasome [PDF]

, 1999
Cristine Alvès da Costa, Karine Ancolio, Frédéric Checler   +2 more
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