Alzheimer's Disease-like Alterations in Peripheral Cells from Presenilin-1 Transgenic Mice
Neurobiology of Disease, 2001 Many cases of early-onset inherited Alzheimer's disease (AD) are caused by mutations in the presenilin-1 (PS1) gene. Expression of PS1 mutations in cell culture systems and in primary neurons from transgenic mice increases their vulnerability to cell ...
Anne Eckert +6 more
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Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum [PDF]
, 2005 In contrast to the common and genetically complex senile form of Alzheimer's disease (AD), the molecular genetic dissection of inherited presenile dementias has given important mechanistic insights into the pathogenesis of degenerative brain disease ...
Cruts, Marc +5 more
core +1 more source
Presenilin/γ-secretase and inflammation
Frontiers in Aging Neuroscience, 2010 Presenilins (PS) are the catalytic components of γ-secretase, an aspartyl protease that regulates through proteolytic processing the function of multiple signaling proteins.
Carlos A Saura
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Pathogenic PSEN1 Thr119Ile Mutation in Two Korean Patients with Early-Onset Alzheimer’s Disease
Diagnostics, 2020 We report a probable pathogenic Thr119Ile mutation in presenilin-1 (PSEN1) in two unrelated Korean patients, diagnosed with early onset Alzheimer’s disease (EOAD). The first patient presented with memory decline when she was 64 years old.
Eva Bagyinszky +8 more
doaj +1 more source
Cell & Bioscience, 2022 Background The mammalian target of rapamycin (mTOR) plays a critical role in controlling cellular homeostasis, and its dysregulation has been implicated in Alzheimer’s disease (AD).
Cheong-Meng Chong +10 more
doaj +1 more source
Village guards as “in between” in the Turkish-Kurdish conflict: Re-examining identity and position in intergroup conflict [PDF]
, 2019 The current paper utilizes new approaches in intergroup conflict studies to examine the village guard system and its role in the Turkish-Kurdish conflict in Turkey.
Acar, Yasemin Gülsüm
core +3 more sources
Role of Presenilin-1 in Aggressive Human Melanoma. [PDF]
Int J Mol Sci, 2022 Presenilin-1 (PS-1), a component of the gamma (γ)-secretase catalytic complex, has been implicated in Alzheimer’s disease (AD) and in tumorigenesis. Interestingly, AD risk is inversely related to melanoma, suggesting that AD-related factors, such as PS-1, may affect melanomagenesis. PS-1 has been shown to reduce Wnt activity by promoting degradation of
Sidor J +4 more
europepmc +3 more sources
Signal peptide peptidases and gamma-secretase: Cousins of the same protease family? [PDF]
, 2007 Signal peptide peptidase (SPIP) is an unusual aspartyl protease, which mediates clearance of signal peptides by proteolysis within the endoplasmic reticulum (ER).
Christian Haass +15 more
core +2 more sources
Evaluación de la producción de b-amiloide por la mutación E280A en el gen de la presenilina 1
Biomédica: revista del Instituto Nacional de Salud, 2007 Introducción. La mutación E280A en el gen de presenilina 1 se encuentra asociada al grupo familiar más grande del mundo con enfermedad de Alzheimer. La presenilina 1 es un componente esencial del complejo g-secretasa, responsable de la producción del ...
Andrés Villegas +5 more
doaj +1 more source
Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction [PDF]
, 2010 Synaptic dysfunction is widely thought to be a pathogenic precursor to neurodegeneration in Alzheimer’s disease (AD), and the extent of synaptic loss provides the best correlate for the severity of dementia in AD patients.
Ho, Angela +5 more
core +1 more source