Results 201 to 210 of about 13,284,993 (240)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Adhesively Bonded Steel-Concrete Composite Structures: A Systematic Literature Review. [PDF]

Materials (Basel)
Rocha A, Valente IB, Aguiar JB.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Marine Durability of Alkali-Activated Materials Under Multi-Ion Attack: Mechanisms, Responses, and Mitigation Strategies. [PDF]

Materials (Basel)
Bai X, Zhou Z, Yue M, Yang L, Gao T, Feng M, Xie N.   +6 more
europepmc   +1 more source

Road Surface Condition Evaluation Using Imaging, LiDAR, and Multi-Grade Navigation Systems. [PDF]

Sensors (Basel)
Eissa AM, Hodaei M, Manish R, Habib A.
europepmc   +1 more source

Integration of Pattern Recognition and Machine Learning with the Acoustic Emission Method to Locate and Assess Corrosion in Cable-Stayed and Suspension Bridge Post-Tensioned Cable Anchorages. [PDF]

Sensors (Basel)
Krampikowska A, Świt G.
europepmc   +1 more source

Comparative Experimental Study of Eco-Composite Reinforced Concrete Beams Under Flexural Loading: Sustainability Factors vs. Mechanical Performance. [PDF]

Polymers (Basel)
Bounjoum Y, Hamlaoui O, Bibridne Y, Tozan H, Duzdar I, Bouktib N, Choab N, El Fqih MA.   +7 more
europepmc   +1 more source

Experimental investigation on the shear strength, consolidation and permeability characteristics of cross-linked biopolymer-stabilized soils. [PDF]

Sci Rep
Kumar MA, Moghal AAB, Dubey BK, Rehman AU.   +3 more
europepmc   +1 more source

Developing Spectrum-Based Models for International Roughness Index and Present Serviceability Index

Journal of Transportation Engineering, 2001
This paper presents a theoretical model for determining international roughness index (IRI) and present serviceability index (PSI) in term of power spectral density (PSD) roughness. Frequency response functions of quarter-car model and CHOLE-type profilometer are obtained by means of stochastic process theory.
Lu Sun
exaly   +2 more sources