Results 211 to 220 of about 933 (249)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Anisotropic Mechanical Properties of 3D Printed Low-Carbon Concrete and Connection Strategies for Large-Scale Reusable Formwork in Digital Construction. [PDF]

Materials (Basel)
Zhu B, Qi M, Chen W, Pan J.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Preparation and Synergistic Activation Mechanism of Cemented Backfill Materials Utilizing MSWI Fly Ash and Low-Titanium Slag. [PDF]

Materials (Basel)
Su B, Chi J, Zhang S, Li J, Li K, Xu X, Ni W.   +6 more
europepmc   +1 more source

Fracture resistance of different overlay designs with novel lithium disilicate materials on 3D printed dies. [PDF]

BMC Oral Health
Atta RS, Aboelfadl A, Rafla NEB.
europepmc   +1 more source

Jointly Optimizing Resource Allocation, User Scheduling, and Grouping in SBMA Networks: A PSO Approach. [PDF]

Entropy (Basel)
Wu J, Liu C, Wang X, Cheng CT, Zhou Q.
europepmc   +1 more source

Surrogate measurement of traffic safety with insights from pavement condition, sensor fusion, and machine learning. [PDF]

Sci Rep
Amani MJ, Golroo A, Hajikarimi P.
europepmc   +1 more source

Study on freeze-thaw cyclic durability of reclaimed ceramic concrete in western high altitude region. [PDF]

Sci Rep
Kuan P, Heyuqiu L, Yaping L.
europepmc   +1 more source

Investigation of multi-performance optimization of banana/bark cloth reinforced epoxy composites using grey relational analysis for automotive interior applications. [PDF]

Sci Rep
Turyahabwe A, Dennison MS, George OS.
europepmc   +1 more source

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Estimation of Present Serviceability Index from International Roughness Index

Transportation Research Record, 1999
An analysis is described that was undertaken with the objective of developing realistic models for estimating present serviceability index (PSI) as a function of international roughness index (IRI) for asphalt and concrete pavements. These models were developed by first analyzing the correlation between slope variance and PSI values obtained in the ...
Kathleen Hall, Carlos Muñoz
exaly   +2 more sources