Results 41 to 50 of about 513,135 (181)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Investigation of stability characteristics of emulsions with (Ziziphus jujube Mill. Oil) water and oil phase vegetable sunflower oil 20, 40 and 60%

Растениевъдни науки
The stability characteristics of model emulsions O/W with stabilizer 20% dry matter from four varieties of Ziziphus jujube (Tiger tooth, Li (with and without spines), China 2A) of Bulgarian origin were studied.
Teodora Petkova, Zhivka Goranova, Petya Tranenska, Todorka Petrova, Zdravko Manev   +4 more
doaj   +1 more source

Analysis of causes of damage to masonry walls in the historic barrack No. B-115 in the former KL Auschwitz II – Birkenau camp [PDF]

MATEC Web of Conferences
The brick barracks in the former German Nazi Concentration and Extermination camp KL Auschwitz II-Birkenau hold historical importance and are protected by law through their inclusion in the register of historical monuments. They are also inscribed on the
Gromysz Krzysztof, Szoblik Łukasz, Drabczyk Zofia, Tanistra-Różanowska Agnieszka   +3 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Successful Fertility Preservation Using Ex vivo Oocyte Retrieval and Transportation in a Case of Stage IB3 Cervical Cancer with a Risk of Ovarian Metastasis

Fertility & Reproduction
This case involved a 31-year-old woman with stage IB3 cervical cancer and suspected obturator lymph node metastasis. The cervical tumor size exceeded 4 cm.
Yuta Kasahara, Tomoko Hashimoto, Airi Kobayashi, Noriyuki Okuyama, Yuriko Fukuoka, Shogo Nishino, Motoko Kanno, Hiroyuki Kanao, Koichi Kyono   +8 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Mechanistic study of the effect of a high-salt diet on the intestinal barrier

Scientific Reports
Despite the established link between chronic high salt diet (HSD) and an increase in gut inflammation, the effect of HSD on the integrity of the intestinal barrier remains understudied.
Li Chen, Junrui Tang, Yanglin Xia, Jie Wang, Li-na Xia   +4 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The woody vegetation communities of the Hluhluwe-Corridor- Umfolozi Game Reserve Complex

Bothalia: African Biodiversity & Conservation, 1983
Land units for the 900 km- Hluhluwe-Corridor-Umfolozi Game Reserve Complex in north eastern Natal were identified on aerial photographs. The physiognomy, dominants and description of the woody vegetation for each unit were identified during ground ...
A. Whateley, R. N. Porter
doaj   +1 more source