Results 111 to 120 of about 1,171,113 (289)

A Simple Approximation of Productivity Scores of Fuzzy Production Plans [PDF]

This paper suggests a simple approximation procedure for the assessment of productivity scores with respect to fuzzy production plans. The procedure has a clear economic interpretation and all the necessary calculations can be performed in a spreadsheet ...
Jens Leth Hougaard
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Characterization of Enteric Disease in Children by Use of a Low-Cost Specimen Preservation Method. [PDF]

J Clin Microbiol, 2021
Debes AK, Xiao S, Liu J, Shaffer A, Scalzo P, Guenou E, Beyala L, Pascal GA, Chebe AN, Tchio-Nighie H, Sonia NS, Ram M, Sack DA, Ateudjieu J.   +13 more
europepmc   +1 more source

Energy-preserving methods for Poisson systems

Journal of Computational and Applied Mathematics, 2012
The authors are concerned with initial value problems attached to systems of ordinary differential equations for which the vector field can be formulated in gradient form. For such problems they introduce and analyze a class of one-step methods which are energy-preserving and are also able to preserve quadratic Casimirs. A numerical test is carried out
BRUGNANO, LUIGI, M. Calvo, I. J. Montijano, L. Randez   +3 more
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Hypothermic Machine Perfusion as a National Standard Preservation Method for Deceased Donor Kidneys. [PDF]

Transplantation, 2022
Brat A, de Vries KM, van Heurn EWE, Huurman VAL, de Jongh W, Leuvenink HGD, van Zuilen AD, Haase-Kromwijk BJJM, de Jonge J, Berger SP, Hofker SH.   +10 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Heart transplantation: comparing the impact of modified heart preservation with conventional methods

Scientific Reports
The purpose of this study was to compare the impact of modified heart preservation techniques with conventional heart preservation techniques on heart transplant recipients. The goal was to determine if these modified preservation techniques could extend
Xiaoke Shang, Changdong Zhang, Yixuan Wang, Mei Liu, Yucheng Zhong, Nianguo Dong   +5 more
doaj   +1 more source

The Influence of the Preservation Method and Gamma Irradiation Sterilization on TGF-β and bFGF Levels in Freeze-Dried Amnion Membrane (FD-AM) and Amnion Sponge. [PDF]

Int J Biomater, 2021
Suroto H, Aryawan DM, Prakoeswa CA.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source