Results 161 to 170 of about 433,325 (294)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Physician estimates of the feasibility of preserving the dying for future revival. [PDF]

PLoS One
Zeleznikow-Johnston A, Kendziorra EF, McKenzie AT.   +2 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Non-Invasive Sampling Reveals Genetic Differentiation and Lineage Structure in the Rare Butterfly <i>Luehdorfia chinensis</i> Leech (Lepidoptera Papilionidae). [PDF]

Ecol Evol
Yang WJ, OuYang HD, Zhu Q, Zou YH, Jiang B, Xu S, Huang GP, Jiang GF, Zeng JP.   +8 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Privacy preservation of data using modified rider optimization algorithm: Optimal data sanitization and restoration model

, 2021
Mohana Shivashankar, Sahaaya Arul Mary
core   +1 more source

Impact of modified Henry approach with preservation of Flexor Carpi Radialis Tendon Sheath on wrist function in the treatment of distal radius fractures. [PDF]

Arch Orthop Trauma Surg
Ma D, Ji J, Zhu Y, Fang X, Wang Y, Fan J.   +5 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Preservation of Data Privacy Using PCA Based Transformation

, 2009
R. Vidya Banu, N. Nagaveni
core   +1 more source

Electronic evidence and the Croatian Criminal Procedure Act

, 2014
Drazen Skrtic, Ph.D., presents the provisions on the temporarily seizure of electronic data, the search and seizure of electronic devices, and considers the rules for the preservation of electronic evidence under the provisions of the Croatian Criminal ...
Skrtic, Drazen
core   +1 more source