Results 151 to 160 of about 7,510,132 (348)

NPC1 promotes the progression of hepatocellular carcinoma by mediating the accumulation of neutrophils into the tumor microenvironment

FEBS Open Bio, Volume 15, Issue 4, Page 661-673, April 2025.
Compared to normal tissues, NPC1 expression is significantly elevated in hepatocellular carcinoma tissues. Our findings indicate that NPC1 plays a key role in regulating neutrophil recruitment within the tumor, which is a critical factor in the progression of hepatocellular carcinoma and is closely linked to poor patient outcomes.
Songhai Yang, Jiangming Chen, Kun Xie, Fubao Liu   +3 more
wiley   +1 more source

Evaluating frailty scores across experimental groups in rodent models: bridging physical and cognitive domains

FEBS Open Bio, Volume 15, Issue 4, Page 599-607, April 2025.
Method for Frailty Score (FS) calculation: (1) Combine all animals that will be compared in one group; (2) Calculate 20% cutoff; (3) Determine the number of animals that ‘failed’ or ‘passed’; (4) Calculate ‘percentage of success’ for graphical representation of parameters; (5) Repeat for all parameters; (6) Calculate FS and use percentages for ...
Aleksandra Mladenovic, Smilja Pracer
wiley   +1 more source

EVALUATION OF HYPERTONIC CITRATE FLUSHING SOLUTION FOR KIDNEY PRESERVATION USING THE ISOLATED PERFUSED RAT KIDNEY

, 1978
Margaret Bishop, B. D. Ross
openalex   +1 more source

Cost‐effective and simple flow cytometry quantification of receptor‐mediated autophagy using fluorescent tagging

FEBS Open Bio, Volume 15, Issue 4, Page 587-598, April 2025.
Mitophagy, the selective degradation of damaged mitochondria, is crucial for cellular health and function. This study introduces a rapid and efficient flow cytometry method using GFP‐BNIP3L/NIX to accurately quantify mitophagy. Our approach can be adapted to use any fluorescent‐tagged selective autophagy receptor, enabling direct and rapid analysis of ...
Mija Marinković, Ana Rožić, Denis Polančec, Ivana Novak   +3 more
wiley   +1 more source

THE INTEGRITY OF TUBULAR CELL FUNCTION AFTER PRESERVATION IN COLLINS' OR SACKS' SOLUTION

, 1976
J. I. Dahlager, Torben Bilde
openalex   +1 more source

Dexmedetomidine suppresses glucose‐stimulated insulin secretion in pancreatic β‐cells

FEBS Open Bio, Volume 15, Issue 4, Page 634-646, April 2025.
Dexmedetomidine decreases insulin release and affects glucose metabolism; however, the specific mechanism remains largely unknown. This study shows clinically relevant doses of dexmedetomidine suppressed glucose‐stimulated insulin secretion. There was no significant difference in oxygen consumption rate, intracellular ATP levels, or caspase‐3/7 ...
Munenori Kusunoki, Kiichi Hirota, Tomohiro Shoji, Takeo Uba, Yoshiyuki Matsuo, Mikio Hayashi   +5 more
wiley   +1 more source

Biochemical Studies in Perfundates and Homogenates of Isolated Porcine Kidneys after Flushing with Zinc or Zinc-Prolactin Modified Preservation Solution Using a Static Cold Storage Technique. [PDF]

Molecules, 2021
Ostróżka-Cieślik A, Dolińska B, Ryszka F.   +2 more
europepmc   +1 more source

24-HOUR RAT LIVER PRESERVATION USING UW SOLUTION AND SOME SIMPLIFIED VARIANTS

, 1989
R Sumimoto, Neville V. Jamieson, Kenjiro Wake, Naoshi Kamada   +3 more
openalex   +1 more source

Prevention of ischemia-reperfusion lung injury during static cold preservation by supplementation of standard preservation solution with HEMO2life® in pig lung transplantation model

Artificial Cells Nanomedicine and Biotechnology, 2017
M. Glorion, V. Polard, F. Favereau, Thierry Hauet, Franck Zal, Elie Fadel, Edouard Sage   +6 more
semanticscholar   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

FEBS Open Bio, Volume 15, Issue 5, Page 773-792, May 2025.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law, Yuan Gao, Sravya Kovvali, Pankajavalli Thirugnanasambantham, Vicki H. Wysocki, Brian M. M. Ahmer, Venkat Gopalan   +6 more
wiley   +1 more source