Results 61 to 70 of about 7,510,132 (348)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

24-hour Perfusion of Porcine Myocutaneous Flaps Mitigates Reperfusion Injury: A 7-day Follow-up Study

Plastic and Reconstructive Surgery, Global Open, 2022
Background:. Static cold storage is the gold standard of preservation in vascularized composite allotransplantation and allows a preservation time of 4–6 hours. Machine preservation is a promising technique for prolonged preservation; however, studies on
Kaj Brouwers, MD, Max F. Thijssen, MD, Anne Sophie Kruit, PhD, Dominique van Midden, MD, Erik J. Koers, BsC, Her J.H. Zegers, Ing., Stefan Hummelink, PhD, Dietmar J.O. Ulrich, MD, PhD   +7 more
doaj   +1 more source

Human colon organoid differentiation from induced pluripotent stem cells using an improved method

FEBS Letters, Volume 599, Issue 6, Page 912-924, March 2025.
We compared established protocols to differentiate induced pluripotent stem cells into colon organoids and found that activation of bone morphogenetic protein 2 signaling induced gene expression of colon‐specific markers. Adenovirus‐mediated transduction of the transcription factors HOXD13 or SATB2 further enhanced colonic gene expression, suggesting ...
I‐Ting Lee, Yu Takahashi, Takashi Sasaki, Yoshio Yamauchi, Ryuichiro Sato   +4 more
wiley   +1 more source

A classification of volume preserving generating forms in R^3 [PDF]

Discrete and Continuous Dynamical Systems - Series A 36.4, pp. 2285-2303 (2016), 2014
In earlier work, Lomeli and Meiss used a generalization of the symplectic approach to study volume preserving generating differential forms. In particular, for the $\mathbb{R}^3$ case, the first to differ from the symplectic case, they derived thirty-six one-forms that generate exact volume preserving maps.
arxiv   +1 more source

Preservation solution supplemented with biliverdin prevents lung cold ischaemia/reperfusion injury.

European Journal of Cardio-Thoracic Surgery, 2012
OBJECTIVES Biliverdin (BV), one of the byproducts of heme catalysis through the heme oxygenase system, is a known scavenger of the reactive oxygen species.
R. Sugimoto, Yugo Tanaka, K. Noda, T. Kawamura, Y. Toyoda, T. Billiar, K. McCurry, A. Nakao   +7 more
semanticscholar   +1 more source

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, Volume 599, Issue 7, Page 1055-1074, April 2025.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

Ethanol fuel improves arthropod capture in pitfall traps and preserves DNA

ZooKeys, 2012
We tested the value of ethanol fuel as a killing solution in terms of sampling efficiency (species richness and accumulated abundance) and DNA preservation of Ensifera ground-dwelling specimens.
Neucir Szinwelski, Verônica Fialho, Karla Yotoko, Léon Seleme, Carlos Sperber   +4 more
doaj   +1 more source

Preservation solutions for attenuation of ischemia–reperfusion injury in vascularized composite allotransplantation

SAGE Open Medicine, 2021
Vascularized composite allotransplantation represents the final level of the reconstructive ladder, offering treatment options for severe tissue loss and functional deficiencies.
Shaishav Datta, Aisling M Fitzpatrick, Siba Haykal   +2 more
doaj   +1 more source

Residues R177 and S178 of the human Na+/H+ antiporter NHA2 are involved in its inhibition by the flavonoid phloretin

FEBS Letters, Volume 599, Issue 6, Page 901-911, March 2025.
The human Na+/H+ antiporter NHA2 transports Na+ or Li+ in exchange for protons across cell membranes, and its dysfunction results in various pathologies, e.g., fertility disorders, hypertension, or diabetes. This work provides the molecular characterization of interactions of NHA2 with its specific inhibitor phloretin, which can be helpful for the ...
Olga Zimmermannova, Martin Kubeš, Tereza Przeczková, Gal Masrati   +3 more
wiley   +1 more source

Liver Preservation With Machine Perfusion and a Newly Developed Cell‐Free Oxygen Carrier Solution Under Subnormothermic Conditions

American Journal of Transplantation, 2015
We describe a new preservation modality combining machine perfusion (MP) at subnormothermic conditions (21°C) with a new hemoglobin‐based oxygen carrier (HBOC) solution.
P. Fontes, R. Lopez, A. Plaats, Y. Vodovotz, M. Minervini, V. Scott, K. Soltys, S. Shiva, Shirish G. Paranjpe, David Sadowsky, Derek A. Barclay, R. Zamora, D. Stolz, A. Demetris, G. Michalopoulos, J. Marsh   +15 more
semanticscholar   +1 more source