Results 111 to 120 of about 9,465,006 (361)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Band gap closure, incommensurability and molecular dissociation of dense chlorine

Nature Communications, 2019
Molecular systems are predicted to transform into atomic solids and be metallic at high pressure; this was observed for the diatomic elements iodine and bromine. Here the authors access the higher pressures needed to observe the dissociation in chlorine,
Philip Dalladay-Simpson, Jack Binns, Miriam Peña-Alvarez, Mary-Ellen Donnelly, Eran Greenberg, Vitali Prakapenka, Xiao-Jia Chen, Eugene Gregoryanz, Ross T. Howie   +8 more
doaj   +1 more source

Increased pain sensitivity in low blood pressure. [PDF]

, 2008
. There is broad evidence for a functional interaction between the cardiovascular and pain regulatory systems. One result of this interaction is the reduced sensitivity to acute pain in individuals with elevated blood pressure, which has been established
Duschek, Stefan, R. Sch, Schandry, Rainer, W. Schwarzkopf, S. Duschek, Schwarzkopf, W.   +5 more
core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Author Correction: Band gap closure, incommensurability and molecular dissociation of dense chlorine

Nature Communications, 2019
The original version of this Article omitted references to previous experimental reports on solid hydrogen that are relevant for a full understanding of the context of the previous work. The added references are: 47. Akahama, Y. et al.
Philip Dalladay-Simpson, Jack Binns, Miriam Peña-Alvarez, Mary-Ellen Donnelly, Eran Greenberg, Vitali Prakapenka, Xiao-Jia Chen, Eugene Gregoryanz, Ross T. Howie   +8 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

The optimal substrate choice for effective biosensors based on THz metasurfaces

Scientific Reports
This article explores the impact of substrate choice on the sensitivity of sensors that utilize metallic terahertz metasurfaces as the actuating element.
Pradeep Tiwari, Deepak Kala, Maciej Sakowicz   +2 more
doaj   +1 more source

Recent advances in synthesis, structure, and properties of binary and ternary transition metal phosphides [PDF]

Matter and Radiation at Extremes
Transition metal phosphides exhibit diverse crystal structures and intriguing physical properties, including superconductivity and magnetism. Despite extensive studies, obtaining a comprehensive understanding of the synthesis methods, structural ...
Xinyue Wang, Xin Yang, Liyunxiao Wu, Jun Deng, Qingyang Hu, Huiyang Gou   +5 more
doaj   +1 more source

Negative Pressure Wound Therapy (NPWT) in Breast Surgery

, 2019
Background: The use of Negative Pressure Wound Dressing has been found to promote the wound healing process, therefore, reducing the risk of surgical site complications. The use of this technique amongst breast cancer patients, who have often encountered
Harsten, Rebecca, SALIH, Vanessa, Asaad, Amira, Banasiewicz, Tomasz, SAAD ABDALLA AL-ZAWI, Abdalla, Alkhir, Momen Abdou, BenRafe, Hamad   +6 more
core   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source