Results 131 to 140 of about 5,609,198 (311)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Pressure-volume loop analysis.

, 2018
LV, left ventricle; SBP, systolic blood pressure; LVESV, left ventricular end-systolic volume; LVEDV, left ventricular end-diastolic volume; LVEDP, left ventricular end-diastolic pressure.
Marek Janotka (5136080), Martin Ostadal (5136077), Andreas Krüger (457043), Pavel Hala (5136074), Petr Ostadal (695304), Svitlana Strunina (5136065), Martin Mates (5136056), Ivo Simundic (5136053), Mikulas Mlcek (5136062), Holger Gorhan (5136071), Petr Neuzil (5136068), James C. Leiter (308134), Otomar Kittnar (3586529), Dagmar Vondrakova (695317), Matej Hrachovina (5136059)   +14 more
core   +1 more source

Enhancing Mn‐Activated Mechanoluminescence via Pressure‐Regulated Local Structure in Centrosymmetric BaZnOS for Dynamic Response Applications

Advanced Science
Self‐recoverable mechanoluminescence (ML), typically observed in non‐centrosymmetric luminescent materials, has recently been reported in centrosymmetric systems such as Mn‐activated BaZnOS.
Hao Wang, Bohao Zhao, Tingting Zhao, Mei Li, Shang Peng, Xuqiang Liu, Yanlong Chen, Jiao An, Sheng Jiang, Yue‐chao Wang, Chuanlong Lin, Wenge Yang   +11 more
doaj   +1 more source

Melting and sublimation of graphene and silicene

Physics of Complex Systems
This study involves molecular dynamics simulations aimed at investigating the crystal structure collapse of graphene, graphite and silicene. It shows that in the case of graphene and graphite, crystal structure collapse is related to the sublimation of ...
Юрий Дмитриевич Фомин, Елена Николаевна Циок, Валентин Николаевич Рыжов   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Ambulatory blood pressure and endothelium-dependent vasodilation in hypertensive patients

, 2000
Endothelial function is important for local vascular regulation and an abnormal endothelium-dependent vasodilatation (EDV) has been observed in subjects with essential hypertension.
von zur Mühlen, Bengt,, Lind, Lars,, Millgård, Jonas,, Sarabi, Mahziar,   +3 more
core   +1 more source

Controllable multicolor emission from initially non-emissive organic molecules by pressure engineering

Nature Communications
Developing smart luminescent materials with off-on switchable responsiveness, which enables dark-to-bright state transitions in response to external stimuli, has garnered great interest across various domains.
Zhihao Xiao, Weibin Wang, Jingkun Yu, Yunfeng Yang, Haifeng Zhu, Siyu Lu, Zhennan Wu, Xinyi Yang, Bo Zou   +8 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source