Results 151 to 160 of about 10,535,256 (359)

Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes

, 2018
Elizabeth F. Sutton, Robbie A. Beyl, Kate Early, William T. Cefalu, Éric Ravussin, Courtney M. Peterson   +5 more
openalex   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Under pressure

eLife, 2016
The movement of water by osmosis causes pressure differences that drive the transport of sugars over long distances in plants.
openaire   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Discovery of the Hailin impact crater in northeast China

Matter and Radiation at Extremes
A uniquely shaped impact structure, the Hailin impact crater, has been discovered in northeast China. The crater was formed on a granodiorite hillside and is an oval depression with asymmetric rim height and a maximum diameter of 1360 m.
Feng Yin, Ming Chen, Wenge Yang, Ho-kwang Mao   +3 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Continuous positive airway pressure versus standard care for the treatment of people with mild obstructive sleep apnoea (MERGE): a multicentre, randomised controlled trial

, 2019
Alison Wimms, Julia L. Kelly, Chris D. Turnbull, Alison McMillan, Sonya Craig, John O’Reilly, Annabel H. Nickol, Emma Hedley, Meredith Decker, Leslee Willes, Peter M.A. Calverley, Adam Benjafield, John Stradling, Mary J. Morrell, Alison Wimms, Julia L. Kelly, Chris D. Turnbull, Alison McMillan, Sonya Craig, John O’Reilly, Annabel H. Nickol, Sophie West, Anita K. Simonds, Shirmila Withana, Justin CT Pepperell, Neil R. Ward, Brian D. Kent, Timothy Quinnell, Mohammad Paracha, William B. Anderson, Emma Hedley, Meredith Decker, Leslee Willes, Peter M.A. Calverley, Adam Benjafield, John Stradling, Mary J. Morrell   +36 more
openalex   +2 more sources

Intensive Continuous Positive Airway Pressure Adherence Program During Stroke Rehabilitation [PDF]

, 2019
Sandeep Khot, Heather Barnett, Arielle Davis, Jenny Siv, Deborah A. Crane, Allison Kunze, Denise Li Lue, Aaron E. Bunnell, Barbara S. McCann, Charles H. Bombardier, W. T. Longstreth, Nathaniel F. Watson, Martha E. Billings   +12 more
openalex   +1 more source