Results 71 to 80 of about 6,842,466 (349)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Analytical and Numerical Contact Stress Analysis of Spur Gears

Science, Engineering and Technology, 2023
The damage that occurs on the teeth flank of cylindrical gears is a complex phenomenon and depends on many factors. The most common cause for these damages is the high contact stress of the meshing gears.
Blagoja Nestorovski, Petar Simonovski
doaj   +1 more source

Design Method of Controllable Blade Angle and Orthogonal Optimization of Pressure Rise for a Multiphase Pump

, 2018
The hydraulic design method of controllable blade angle for rotodynamic multiphase pump with impeller and diffuser is proposed. The distribution of blade angle along the meridional streamline is governed by the normalized fourth-order and first-order ...
M. Liu, L. Tan, S. Cao
semanticscholar   +1 more source

Analysis of pressure, angle and temporal effects on tissue optical properties from 
polarization-gated spectroscopic probe measurements

Biomedical Optics Express, 2010
Noninvasive optical techniques for tissue characterization, in particular, light scattering properties and blood supply quantification of mucosa, is useful in a wide variety of applications.
S. Ruderman, A. Gomes, V. Stoyneva, J. Rogers, A. Fought, B. Jovanovic, V. Backman   +6 more
semanticscholar   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Impact of Phacoemulsification Surgery on Intraocular Pressure in Primary Angle-Closure Glaucoma

, 2012
Pur po se: To investigate whether primary phacoemulsification in acute primary angle closure glaucoma (APACG) and chronic primary angle closure glaucoma (CPACG) will lower intraocular pressure (IOP) or not.
Volkan Dayanır, Aykut Özdemir, Ahmet Kaplan, Esin Kırıkkaya   +3 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Systemic medications and other risk factors of open-angle glaucoma [PDF]

, 2012
Het onderzoek in dit proefschrift is ontworpen om de werking van sommige systemische geneesmiddelen te ontcijferen en een aantal andere risicofactoren van open-kamerhoek glaucoom (OKG) te onderzoeken.
Marcus, Michael Williams, Marcus, Michael Williams,   +1 more
core  

Effect of different electrode tip angles with tilted torch in stationary gas tungsten arc welding : A 3D simulation

, 2013
In this study, the effect of different tip angles (30°, 60°, 90° and 120°) on the arc and weld pool behaviour is analysed in 2mm and 5mm arc lengths with tilted (70°) torch.
Parvez, Shahid, Abid, Muhammad, Nash, David   +2 more
core   +1 more source

GWAS-by-subtraction reveals an IOP-independent component of primary open angle glaucoma

Nature Communications
The etiology of primary open angle glaucoma is constituted by both intraocular pressure-dependent and intraocular pressure-independent mechanisms.
Yu Huang, Denis Plotnikov, Huan Wang, Danli Shi, Cong Li, Xueli Zhang, Xiayin Zhang, Shulin Tang, Xianwen Shang, Yijun Hu, Honghua Yu, Hongyang Zhang, Jeremy A. Guggenheim, Mingguang He   +13 more
doaj   +1 more source