Results 111 to 120 of about 24,188,873 (354)

Electrochromic orbit control for smart-dust devices [PDF]

, 2012
Recent advances in MEMS (micro electromechanical systems) technology are leading to spacecraft which are the shape and size of computer chips, so-called SpaceChips, or ‘smart dust devices’.
Atchison J. A., Camilla Colombo, Charlotte Lücking, Colin R. McInnes, Colombo C., De Juan Ovelar M., Kawaguchi J., Krivov A. V., Lücking C., Oyama T., Schaub H., Stark J. P. W.   +11 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Simulation Research on Pressure Control Performance of Thermodynamic Venting System of Rocket Propellant Tank

Zhileng xuebao, 2019
This article described the composition and working principle of the thermodynamic venting system (TVS) for the in-orbit management of cryogenic propellants.
Xia Siqi, Sun Peijie, Li Peng, Wang Changhuan, Wang Lei, Li Yanzhong   +5 more
doaj  

Changes in the prevalence, treatment and control of hypertension in Germany? : a clinical-epidemiological study of 50.000 primary care patients [PDF]

, 2012
INTRODUCTION: Medical societies have developed guidelines for the detection, treatment and control of hypertension (HTN). Our analysis assessed the extent to which such guidelines were implemented in Germany in 2003 and 2001. METHODS: Using standardized
Einsle, Franziska, Klotsche, Jens, Labeit, Alexander Michael, Lehnert, Hendrik, März, Winfried, Pieper, Lars, Pittrow, David, Silber, Sigmund, Stalla, Günter K., Wehling, Martin, Wittchen, Hans-Ulrich, Zeiher, Andreas Michael   +11 more
core   +2 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Experimental Verification of a Two-Motor-Two-Pump Motor-Controlled Hydraulic Cylinder with Throttle-Free Passive Load-Holding Capability in Four-Quadrant Operations

Actuators
Among various motor-controlled hydraulic cylinder (MCC) topologies, the two-motor-two-pump (2M2P) MCC distinguishes itself through several notable advantages, including precise cylinder pressure control and eliminating mode switch oscillations ...
Wei Zhao, Morten Kjeld Ebbesen, Michael Rygaard Hansen, Torben Ole Andersen   +3 more
doaj   +1 more source

Estimating the future burden of cardiovascular disease and the value of lipid and blood pressure control therapies in China

BMC Health Services Research, 2016
BackgroundLifestyle and dietary changes reflect an ongoing epidemiological transition in China, with cardiovascular disease (CVD) playing an ever-increasing role in China’s disease burden.
Warren Stevens, D. Peneva, Jim Z. Li, Larry Z. Liu, Gordon Liu, R. Gao, D. Lakdawalla   +6 more
semanticscholar   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Pressure Control for a Hydraulic Cylinder Based on a Self-Tuning PID Controller Optimized by a Hybrid Optimization Algorithm

Algorithms, 2017
In order to improve the performance of the hydraulic support electro-hydraulic control system test platform, a self-tuning proportion integration differentiation (PID) controller is proposed to imitate the actual pressure of the hydraulic support.
Ru Wang, Chao Tan, Jing Xu, Zhongbin Wang, Jingfei Jin, Yiqiao Man   +5 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source