Results 71 to 80 of about 3,986,628 (294)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Flow Field Simulation for High Speed Train Gearbox
机车电传动, 2017 Regarding the gearbox of a certain type high speed train as the research object, the simulation and analysis of the complex internal flow field during its normal operation was carried out. Three-dimensional model of the gearbox oil lubrication was built,
YANG Zhongkun +3 more
doaj
, 2015 The stability of magnetized strange quark matter (MSQM) is studied in the MIT bag model with the density dependent bag pressure. In the consistent thermodynamic description of MSQM, the quark chemical potentials, the total thermodynamic potential and the
Isayev, A. A.
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
, 2018 An important feature of strong correlated electron systems is the tunability between interesting ground states such as unconventional superconductivity and exotic magnetism. Pressure is a clean, continuous and systematic tuning parameter. However, due to
Chen, Yang +10 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Impact of Magnetic Fields on Arc Pressure, Temperature, Plasma Velocity, and Voltage in TIG Welding
MicromachinesA longitudinal magnetic field provides a new method for regulating the plasma velocity, pressure field, and temperature field of the TIG welding arc. However, the mechanism of action of the longitudinal magnetic field remains poorly understood.
Gang Chen +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Frontiers in AnesthesiologyIntroductionEnsuring hemodynamic stability with adequate perfusion to vital organs is critical to the safe conduct of anesthesia. Recent advances in hemodynamic monitoring technologies allow pressure, flow, and resistance to be measured continuously ...
Stephen F. Woodford +10 more
doaj +1 more source