Results 81 to 90 of about 87,970 (262)

Study on Pressure Fluctuation Characteristics of Hydraulic Pulsed Jet

Shiyou jixie, 2016
By producing instantaneous negative pressure and pulse shock at the bottomhole,the pulsed jet could reduce the pressure holding effect on the cuttings and improve the efficiency of rock breaking and cutting removing.On the basis of the established ...
Zhang Yi, Li Gensheng, Shi Huaizhong, Wei Minghui   +3 more
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Similarity scaling of pressure fluctuation in turbulence

Physical Review E, 2003
Pressure fluctuation was measured in a turbulent jet using a condenser microphone and piezoresistive transducer. The power-law exponent and proportional constant of normalized pressure spectrum are discussed from the standpoint of Kolmogorov universal scaling.
Yoshiyuki, Tsuji, Takashi, Ishihara
openaire   +3 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Prediction of Gas–Liquid Two‐Phase Flow Pressure Wave in the Wellbore During the Re‐Production of Deep Gas Wells

Energy Science & Engineering
The pressure of the tube at the wellhead is abruptly released during the opening of a high‐production gas well, causing pressure fluctuation and subjecting the tubing to extra stress.
Yushan Zheng, Shengli Chu, Sixi Zhang, Pengcheng Wang, Yanlong Li, Yinghua Jing, Bingcai Sun, Zhi Zhang, Jiawei Wang   +8 more
doaj   +1 more source

Experimental study on the influence of air injection on unsteady cloud cavitating flow dynamics

Advances in Mechanical Engineering, 2016
The main purpose of this study was to investigate the influence of air-injection technique on unsteady cloud cavitating flow dynamics. High-speed camera and pressure measurement system are used to record ventilated cavitation images and wall-pressure ...
Naimin Zhang, Yang Zhao, Haipeng Wei, Guanghao Chen   +3 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source