Results 41 to 50 of about 4,048,426 (298)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Can interface conditions be modified by support surfaces to minimise the risk of pressure ulcer development? [PDF]
, 2011 PhDThe characteristics of a patient support interface can influence the susceptibility of subjects, particularly there who are immobilised and insensate, to pressure ulcer development.
Chai, Chanyuan
core +4 more sources
The interaction and pharmacological modulation of the cardiorespiratory responses to primary thoracic blast injury, haemorrhage resuscitation [PDF]
, 2002 Blast injuries represent a problem for civilian and military populations. The response to thoracic blast injury involves a reflex bradycardia, hypotension and apnoea.
Sawdon, Mariana Annette +2 more
core
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
AMELİYAT GEÇİREN HASTALARDA BASINÇ YARALANMALARININ ÖNLENMESİ
Sakarya Üniversitesi Holistik Sağlık Dergisi, 2020 Basınç yaralanması, tüm dünyada olduğu gibi ülkemizde de sık görülen, hastanın ağrı ve acı çekmesine yol açarak yaşam kalitesini etkileyen ve sağlık bakımına mali yük getiren önemli bir sağlık sorunudur.
Selda Rızalar
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
On the Origin of Intraoperative Pressure Injury: An Angiosomal Theory of Pressure Injury Formation [PDF]
Advances in Wound Care, 2019 We review a case of a 22-year-old healthy man who underwent a 5-h maxillofacial surgery while continuously supine with foam pads placed prophylactically over elevated heels. Immediately after surgery, Stage 1 pressure injuries appeared on the left lateral heel and right lateral ankle, despite the absence of local pressure to these areas.
Caroline E. Fife, Efthymios Gkotsoulias
openaire +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Frontiers in Public HealthIntroductionPressure injury (PI) is a significant concern in Chinese nursing homes, particularly in China, especially due to the rapidly aging population.
Yanxia Guo +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source