Results 41 to 50 of about 778,993 (303)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

The interaction and pharmacological modulation of the cardiorespiratory responses to primary thoracic blast injury, haemorrhage resuscitation [PDF]

, 2002
Blast injuries represent a problem for civilian and military populations. The response to thoracic blast injury involves a reflex bradycardia, hypotension and apnoea.
Sawdon, Mariana Annette, Sawdon, Marina Annette, Sawdon, Marina   +2 more
core  

Pressure injury prevalence and predictors among older adults in the first 36-hours of hospitalisation.

, 2019
To describe the prevalence and predictors of pressure injuries among older adults with limited mobility, within the first 36-hours of their hospital admission in Australia.
McInnes, Elizabeth, Sharon Latimer, Gillespie, Brigid M, Lukman Thalib, Elizabeth McInnes, Thalib, Lukman, Latimer, Sharon, Brigid M. Gillespie, Tracey Bucknall, Chaboyer, Wendy, Wendy Chaboyer, Bucknall, Tracey   +11 more
core   +1 more source

Implementation and evaluation of multilayered pressure injury prevention strategies in an Australian intensive care unit setting

, 2021
Background: Pressure injuries are a ubiquitous, yet largely preventable, hospital acquired complication commonly seen in critically ill patients in the intensive care unit.
Doubrovsky, A, Campbell, J, Fulbrook, P, Coyer, F, Cook, JL, McNamara, G, Hartel, G, Vann, A, Edward, KL   +8 more
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

AMELİYAT GEÇİREN HASTALARDA BASINÇ YARALANMALARININ ÖNLENMESİ

Sakarya Üniversitesi Holistik Sağlık Dergisi, 2020
Basınç yaralanması, tüm dünyada olduğu gibi ülkemizde de sık görülen, hastanın ağrı ve acı çekmesine yol açarak yaşam kalitesini etkileyen ve sağlık bakımına mali yük getiren önemli bir sağlık sorunudur.
Selda Rızalar
doaj  

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

On the Origin of Intraoperative Pressure Injury: An Angiosomal Theory of Pressure Injury Formation [PDF]

Advances in Wound Care, 2019
We review a case of a 22-year-old healthy man who underwent a 5-h maxillofacial surgery while continuously supine with foam pads placed prophylactically over elevated heels. Immediately after surgery, Stage 1 pressure injuries appeared on the left lateral heel and right lateral ankle, despite the absence of local pressure to these areas.
Caroline E. Fife, Efthymios Gkotsoulias
openaire   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Development of a social learning theory-based pressure injury training program for nursing assistants in Chinese nursing homes

Frontiers in Public Health
IntroductionPressure injury (PI) is a significant concern in Chinese nursing homes, particularly in China, especially due to the rapidly aging population.
Yanxia Guo, Yanxia Guo, Shengnan Yang, Plernpit Boonyamalik, Arpaporn Powwattana, Wen Zhu, Lingxia Xu   +6 more
doaj   +1 more source