Results 101 to 110 of about 58,196 (307)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
The PRESUMPTION of INNOCENCE in ADMINISTRATIVE JURISDICTION
, 2021 The presumption of innocence is accepted by its position in all international and regional human rights treaties as a standard of fair trials, which like that Continental Law System.
Çayan, Gökhan
core
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
In Search of the Presumption of Regularity
, 2021 The presumption of regularity is an imprecise quasi-deference principle that federal courts apply in varying ways to presume federal officers and employees lawfully and consistently discharge their official duties.
Platt, Steven, Gavoor, Aram A
core +1 more source
The Puzzling Presumption of Reviewability
, 2014 The presumption in favor of judicial review of agency action is a cornerstone of administrative law, accepted by courts and commentators alike as both legally appropriate and obviously desirable. Yet the presumption is puzzling.
Bagley, Nicholas
core +2 more sources
Renewing adjustment of the conception of Serra Domínguez on the evidence and the presumption
Ars Iuris Salmanticensis, 2019 This paper examines the various concepts on presumption that have been exposed by the doctrine, jurisprudence and positive law, indicating the prevailing conception, showing the contribution of Manuel Serra Domínguez.
Rodrigo RIVERA MORALES
doaj
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
A puzzling presumption: determining the presumption of innocence's place in the law
, 2017 The presumption of innocence is widely considered important, included in most human rights agreements, and considered fundamental to trial. Despite this, the presumption of innocence has no agreed upon place in the law. Where does it fit in?
Coleman, M.
core
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source