Results 111 to 120 of about 452,364 (380)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A Minimalist and Garantistic Conception of the Presumption of Innocence

Revista Brasileira de Direito Processual Penal, 2018
The article aims to address the multiple faces that the presumption of innocence incorporates in modern legal systems from a critical perspective. In this sense, an analytical methodology seeks to demonstrate that some of these faces overlap with other ...
Jordi Ferrer Beltrán
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Pretpostavka nevinosti okrivljenog kao element prava na pravično suđenje [PDF]

Revija za kriminologiju i krivično pravo
Although the presumption of innocence has its roots in the rational criminal procedure of the ancient times, it should still be seen as a result of the modern criminal procedure system, i.e.
Drago Radulović
doaj   +1 more source

False Presumptions Counter to the Presumptions of Innocence

Journal of the American Institute of Criminal Law and Criminology, 1917
American criminal procedure is condemned as ineffective, because delay and technicality intervene on behalf of the accused. The sanction of the law is neither swift nor inexorable. Not only do "the wicked flee where no man pursueth," but the prisoner enmeshed is preserved from punishment by over-sedulous respect for his rights. Mr.
openaire   +2 more sources

The Comparative Analysis on the Presumption of Cartel Agreements Which is Unique in the Korean Cartel Regulation Provision [PDF]

, 2005
In terms of cartel regulation, Korea has a “presumption of agreement” provision that does not exist in the United States or in the European Union (EU). This provision is Article 19(5) of the Monopoly Regulation and Fair Trade Act (MRFTA).
Jon, Woo-Jong
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

The Fallacy of Misplaced Presumption

Argumentation, 2023
One takes one's word that p when a source vouches for p and one accepts the word of that source. If the source is reliable in this case, p is acceptable. The reliability of the source is a measure of its plausibility. If a source has the relevant competence, credibility, authority, that word is acceptable.
openaire   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Renewing adjustment of the conception of Serra Domínguez on the evidence and the presumption

Ars Iuris Salmanticensis, 2019
This paper examines the various concepts on presumption that have been exposed by the doctrine, jurisprudence and positive law, indicating the prevailing conception, showing the contribution of Manuel Serra Domínguez.
Rodrigo RIVERA MORALES
doaj