Results 131 to 140 of about 59,071 (329)

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

Conviction of the Innocent; from the Judicial Error to the Real Innocence [PDF]

open access: yesFaṣlnāmah-i Pizhūhish-i Huqūq-i Kiyfarī, 2014
Wrongful conviction of the innocent is a type of miscarriage of justice. Thus, the perspective that believes these two concepts are equivalent is false. Innocence can be actual or legal. The actual innocent is who does not commit the crime.
Muhammad Farajiha, Jamshid Gholamlou
doaj  

The Relevance of Judicial Procedure for Economic Growth [PDF]

open access: yes
It has been argued that procedural formalism undermines economic efficiency by fostering rent-seeking and corruption. We challenge this view by arguing that a number of judicial procedures foster economic growth by increasing the predict-ability of court
Bernd Hayo, Stefan Voigt
core  

Принцип презумпции невиновности в украинском законодательстве [PDF]

open access: yes, 2013
В статье раскрывается значение одного из важнейших принципов правосудия – презумпции невиновности. Проводится исследование происхождения данного принципа, как в историческом, так и в практическом аспектах.In this article it is discovered the meaning of ...
Гаряева, Анна Михайловна   +1 more
core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

CONSIDERATIONS ON THE PRINCIPLE OF PRESUMPTION OF INNOCENCE, ITS EVOLUTION IN BRAZILIAN LAW AND THE POSSIBLE IMPUNITY PRINTING IMPOSED BY THE TRIAL HABEAS CORPUS 84.078

open access: yesTravessias, 2013
This research will seek to analyze, through a study of jurisprudence and doctrinal understanding as constitutional by the Supreme Court in the trial of Habeas 84,078, which declared unconstitutional the provisional execution of the sentence and the ...
Bruno Rafael Cipriano, Ricardo Feistler
doaj  

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