Results 41 to 50 of about 545,325 (314)

The Role of SUMO1 Modification of SOX9 in Cartilage Development Stimulated by Zinc Ions in Mice

Organogenesis
Zinc ions play a pivotal role in facilitating the development of cartilage in mice. Nevertheless, the precise underlying mechanism remains elusive. Our investigation was centered on elucidating the impact of zinc deficiency on cartilage maturation by ...
Na Xue, Jing Zhao, Jing Yin, Liang Liu, Zhong Yang, Shuchao Zhai, Xiyun Bian, Xiang Gao   +7 more
doaj   +1 more source

SENP1‐Mediated HSP90ab1 DeSUMOylation in Cardiomyocytes Prevents Myocardial Fibrosis by Paracrine Signaling

Advanced Science
Myocardial infarction (MI) triggers a poor ventricular remodeling response, but the underlying mechanisms remain unclear. Here, the authors show that sentrin‐specific protease 1 (SENP1) is downregulated in post‐MI mice and in patients with severe heart ...
Zhihao Liu, Xiyun Bian, Lan Li, Li Liu, Chao Feng, Ying Wang, Jingyu Ni, Sheng Li, Dading Lu, Yanxia Li, Chuanrui Ma, Tian Yu, Xiaolin Xiao, Na Xue, Yuxiang Wang, Chunyan Zhang, Xiaofang Ma, Xiumei Gao, Xiaohui Fan, Xiaozhi Liu, Guanwei Fan   +20 more
doaj   +1 more source

Preterm infants have deficient monocyte and lymphocyte cytokine responses to Group B Streptococcus [PDF]

, 2011
Group B streptococcus GBS) is an important cause of early-and late-onset sepsis in the newborn. Preterm infants have markedly increased susceptibility and worse outcomes, but their immunological responses to GBS are poorly defined.
Richmond, P., Strunk, T., Curtis, S., Simmer, K., Burgner, D., Currie, A.J., Doherty, D., Liyanage, K., Riley, K., Prescott, S.   +9 more
core  

Development of the preterm gut microbiome in twins at risk of necrotising enterocolitis and sepsis [PDF]

, 2013
The preterm gut microbiome is a complex dynamic community influenced by genetic and environmental factors and is implicated in the pathogenesis of necrotising enterocolitis (NEC) and sepsis.
Christopher J Stewart, Berrington, Janet E., Andrew Nelson, Cummings Stephen P., Nelson Andrew, Stewart, Christopher, Janet E Berrington, Marrs, Emma, Stephen P Cummings, Embleton, Nicholas D., Janet E. Berrington (452418), Lanyon Clare, Stewart, Christopher J., Perry John D., Berrington, Janet, Stephen P. Cummings (106316), Cummings, Stephen, Emma C. L. Marrs (452415), Perry, John, Nicholas D. Embleton (177535), Embleton Nicholas D., Berrington Janet E., Nelson, Andrew, Cummings, Stephen P., Christopher J. Stewart (452414), Clare Lanyon (452416), Stewart Christopher J., Embleton, Nicholas, Andrew Nelson (209359), Perry, John D., Emma C L Marrs, John D Perry, Clare Lanyon, Marrs, Emma C.L., Lanyon, Clare, John D. Perry (452417), Nicholas D Embleton, Marrs Emma C. L.   +37 more
core   +1 more source

Exploring the lived experiences of mothers of extremely preterm infants within the UK: An interpretative phenomenological analysis

, 2023
Background: The adverse impact of preterm birth on maternal mental health is well documented, yet there is limited available research regarding the subjective experiences of mothers of extremely preterm infants as a distinct cohort.
Jackson, J., Robinson, S, Williams, S., Hallam, J., Stephanie Robinson, Jenny Hallam, Sophie Williams, Jessica Eve Jackson   +7 more
core   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

Advanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang, Xinyuan Li, Lixia Huang, Xiangcai Zhang, Wujian Ke   +4 more
wiley   +1 more source

Short-term Outcomes of Preterm Infants in a Medical Center at Banyumas Regency, Indonesia: A Preliminary Study

Babali Nursing Research, 2020
Introduction: Short-term outcomes of preterm infants refers to any preterm infants’ conditions after birth including medical diagnosis or morbidity, length of stay at the hospital, and readmission to hospital after discharge.
Haryatiningsih Purwandari, Mei-Chih Huang   +1 more
doaj   +1 more source

Antimicrobial skin peptides in premature infants: Comparison with term infants and impact of perinatal factors

Frontiers in Immunology, 2023
IntroductionPreterm infants have an immature epidermis barrier function that may lead to an increased permeability to pathogens. On the surface of the human skin, antimicrobial peptides (AMPs) are important molecules of the innate immune system, have ...
Alexander Humberg, Alexander Humberg, Lisa Neuenburg, Hannah Boeckel, Mats Ingmar Fortmann, Christoph Härtel, Egbert Herting, Heilwig Hinrichs, Franziska Rademacher, Jürgen Harder   +9 more
doaj   +1 more source

Moving the preterm infant [PDF]

BMJ, 2004
Many different health service models for providing neonatal intensive care have been established over the past 30 years, and much of the developed world is moving towards a centralised model of care. At least initially, preterm infants often require specialised care in an intensive care setting.
Peter W, Fowlie, Philip, Booth, Charles H, Skeoch   +2 more
openaire   +2 more sources