Results 191 to 200 of about 410,516 (265)

Targeted Delivery of Indole‐3‐Pyruvic Acid Suppresses Macrophage Ferroptosis to Enhance CD8+ T Cell‐Mediated Immunotherapy Response in Bladder Cancer

Advanced Science, EarlyView.
A microbiota‐derived metabolite, indole‐3‐pyruvic acid, suppresses macrophage ferroptosis through the AHR–NF‐κB–SLC7A11 axis. This preserves CD8+ T cell function in bladder cancer. Macrophage‐targeted nanoparticles enhance indole‐3‐pyruvic acid delivery and overcome resistance to PD‐1 blockade.
Jianwen Lao, Xinhao Yuan, Shuai Liang, Kai Deng, Daqin Wu, Longhao Xu, Kun Zheng, Yi Lin, Peicong Cai, Haoran Zheng, Junyu Chen, Mingli Luo, Yan Chen, Xiong Chen, Chunhui Wang, Wenlong Zhong   +15 more
wiley   +1 more source

Enhanced methane from co-digestion of wheat straw and sludge with KMnO₄ and zero-valent iron. [PDF]

iScience
Wang X, Huang J, Zhang T, Zhang G, Zhao Z.   +4 more
europepmc   +1 more source

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

Advanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang   +12 more
wiley   +1 more source

Disease burden of untreated thymidine kinase 2 deficiency: insights from a large patient dataset. [PDF]

Brain Commun
Domínguez-González C, Garone C, Nascimento A, Ma Y, Boudiaf N, Kim R, VanMeter S, Brunnert M, Hirano M.   +8 more
europepmc   +1 more source

Kinetic‐Directed Thermodynamic Repair Enables the Synthesis of High‐Strain 2D Sub‐Stoichiometric COFs

Advanced Science, EarlyView.
2D covalent organic frameworks are promising photocatalysts. Yet, precise synthesis of sub‐stoichiometric COFs remains challenging due to poor kinetic control. We propose a general strategy: tuning polymerization degree of kinetic intermediates via time or solvent polarity directs their thermodynamic repair into highly crystallization. Using [4+3]‐type
Xiang Pei, Kaifu Yu, Pan He, Hongqing Wu, Bo Jiang, Kewen Shu, Yang Li, Ya Tang, Lijian Ma   +8 more
wiley   +1 more source

Ethanol application enhances freezing stress tolerance in Arabidopsis and sugar beet. [PDF]

Plant Mol Biol
Todaka D, Nakaminami K, Matsui A, Ikeda S, Do QTN, Tanaka M, Takahashi S, Torii C, Ishida J, Takeda T, Nagano AJ, Seki M.   +11 more
europepmc   +1 more source

Hydrogen Sulfide Rescues Microglia From HIV Tat-Driven Ferroptosis: Implications for HIV-Associated Neuroinflammation. [PDF]

CNS Neurosci Ther
Ahsan AU, Martínez-Cuevas FL, Horanieh E, Singh S, Deshetty UM, Periyasamy P, Buch S.   +6 more
europepmc   +1 more source

Concurrent pretreatment serum and BALF galactomannan positivity as a prognostic indicator in non-neutropenic invasive pulmonary aspergillosis without malignancy or solid organ transplantation: a retrospective cohort study. [PDF]

Front Med (Lausanne)
Tang D, Xiong Q, Wang Y, Luo X, Jia J, Feng Y, Zhou W.   +6 more
europepmc   +1 more source

Dapagliflozin attenuates cisplatin-induced nephrotoxicity in rats through modulation of ROS/NF-κB, BCL2/Bax and PINK1/Parkin signaling pathways. [PDF]

Sci Rep
Khallaf EK, Ramadan EA, Elmazar MM, Safar MM.   +3 more
europepmc   +1 more source