Results 121 to 130 of about 6,466,594 (289)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Current Trends in Child Abuse Prevention and Fatalities: The 2000 Fifty State Survey [PDF]

open access: yes, 2002
This survey takes a closer look at two pressing needs. The first is the important role of prevention, specifically at the most effective prevention programs and how they are funded.
Ching-Tung Wang   +3 more
core  

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Statins for primary and secondary prevention in the oldest old : an overview of the existing evidence [PDF]

open access: yes, 2012
Hypercholesterolemia, although a modifiable risk factor for cardiovascular disease, is still one of the leading causes of death among older people in western countries.
Petrovic, Mirko   +2 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Best Practices in Consent Education: An Analysis [PDF]

open access: yes, 2019
The need for sexual assault prevention work on college campuses is largely accepted; however, higher education and student affairs professionals continue to debate the best way to do this work.
Heenehan, Fonda Marguerite
core   +1 more source

Lost in translation? Theory, policy and practice in systems-based environmental approaches to obesity prevention in the Healthy Towns programme in England.

open access: yes, 2014
This paper explores how system-wide approaches to obesity prevention were 'theorised' and translated into practice in the 'Healthy Towns' programme implemented in nine areas in England.
Cummins, Steven   +6 more
core   +1 more source

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