Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
The challenge of secondary prevention for coronary heart disease in older patients: findings from the British Women's Heart and Health Study and the British Regional Heart Study [PDF]
, 2004 Debbie A. Lawlor
openalex +1 more source
Couple Efficacy and Communal Coping for HIV Prevention Among Kenyan Pregnant Couples
, 2022 Pamela Musoke +7 more
openalex +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Disentangling Responsibility: Perspectives on Dementia Prevention From Stakeholders in Canada, Germany and Switzerland. [PDF]
Sociol Health IllnPetersen N +5 more
europepmc +1 more source
Additional Injury Prevention Criteria for Impact Attenuation Surfacing Within Children's Playgrounds [PDF]
, 2018 David Eager, Hasti Hayati
openalex +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Eliminating Syphilis fromth e United States
DST, 1999 NationaJ Center of HIV, STD, and TB Prevention Center for Diseas e Control and Prevention , Atlanta - USA
doaj
Visible Pregnancy, Invisible HIV: How Social Norms Shape Adolescents Protection Choice in Kenya and Nigeria. [PDF]
Ann Glob HealthBitère C +3 more
europepmc +1 more source