Results 181 to 190 of about 8,076,451 (351)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
International Comparison of Daily Smoking Rates among OECD Countries (2023). [PDF]
Public Health Wkly RepKim D.
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Comment on Echouffo-Tcheugui et al. Is the Current Lifestyle Modification Approach to Diabetes Prevention in the U.S. a Success? Diabetes Care 2025;48:863-870. [PDF]
Diabetes CareKuo S +4 more
europepmc +1 more source
Acta clinica Croatica, 2010 Prevention is still the best approach to stroke. Th e goal of prevention is to reduce stroke risk by reducing it’s risk factors. Th e most common risk factors include hypertension, elevated serum lipids, myocardial infarction, atrial fi brillation and carotid stenosis, diabetes, smoking and alcohol consumption, inappropriate diet and inadequate ...
openaire +3 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
When health systems invest matters: temporal imbalance and the case for life-course reorientation. [PDF]
J Glob HealthTian J, Tang L.
europepmc +1 more source