Results 91 to 100 of about 54,982 (232)

Asymptomatic/submicroscopic Plasmodium vivax infection: A systematic review and META-analysis on the hidden challenge for preventing re-establishment of malaria transmission

Parasite Epidemiology and Control
Plasmodium vivax is not only the second most prevalent cause of malaria worldwide, but also the second leading cause of imported malaria in China. This poses a significant threat to preventing the re-establishment of malaria transmission, as the competent vector (Anopheles sinensis) suitable for vivax malaria transmission is widely distributed in China.
Wang, Siqi, Yan, He, Zhang, Li, Xia, Zhigui, Yin, Jianhai   +4 more
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Achieving universal access and moving towards elimination of new HIV infections in Cambodia

Journal of the International AIDS Society, 2014
Introduction In the mid‐1990s, Cambodia faced one of the fastest growing HIV epidemics in Asia. For its achievement in reversing this trend, and achieving universal access to HIV treatment, the country received a United Nations millennium development ...
Mean Chhi Vun, Masami Fujita, Tung Rathavy, Mao Tang Eang, Seng Sopheap, Samreth Sovannarith, Chhea Chhorvann, Ly Vanthy, Oum Sopheap, Emily Welle, Laurent Ferradini, Chin Sedtha, Sok Bunna, Robert Verbruggen   +13 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Mandatory surveillance of bacteremia conducted by automated monitoring

Frontiers in Public Health
Except for a few countries, comprehensive all-cause surveillance for bacteremia is not part of mandatory routine public health surveillance. We argue that time has come to include automated surveillance for bacteremia in the national surveillance systems,
Kåre Mølbak, Kåre Mølbak, Christian Østergaard Andersen, Christian Østergaard Andersen, Ram B. Dessau, Ram B. Dessau, Ram B. Dessau, Svend Ellermann-Eriksen, Sophie Gubbels, Thøger Gorm Jensen, Jenny Dahl Knudsen, Brian Kristensen, Lisbeth Lützen, John Coia, Bente Ruth Scharvik Olesen, Mette Pinholt, Flemming Scheutz, Ute Wolff Sönksen, Kirstine K. Søgaard, Marianne Voldstedlund   +19 more
doaj   +1 more source

Corrigendum

Journal of the International AIDS Society, 2014
Introduction In the mid‐1990s, Cambodia faced one of the fastest growing HIV epidemics in Asia. For its achievement in reversing this trend, and achieving universal access to HIV treatment, the country received a United Nations millennium development ...
Mean Chhi Vun, Masami Fujita, Tung Rathavy, Mao Tang Eang, Seng Sopheap, Samreth Sovannarith, Chhea Chhorvann, Ly Vanthy, Oum Sopheap, Emily Welle, Laurent Ferradini, Chin Sedtha, Sok Bunna, Robert Verbruggen   +13 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Anthrax outbreak: exploring its biological agents and public health implications

Frontiers in Tropical Diseases
The (re)emergence of several infectious zoonoses underlines the need for the re-evaluation of the transmission patterns and key players responsible for effective inter-species transfer of diseases.
Seto C. Ogunleye, Mercy M. Olorunshola, Kolapo A. Fasina, Abdullahi T. Aborode, Olalekan C. Akinsulie, Abimbola Amoo, Boluwatife J. Olatoye, Akeem Bakare, Mariam A. Lawal, Oluwabori Adekanye, Ezemba C. Chinyere   +10 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Knowledge, attitude and practice levels regarding malaria among the Semai sub-ethnic indigenous Orang Asli communities in Pahang, Peninsular Malaysia: a stepping stone towards the prevention of human malaria re-establishment

Malaria Journal
In Malaysia, despite a decline in cases, malaria remains a major public health concern, especially among the vulnerable indigenous people (i.e. Orang Asli) in remote areas. Effective preventive and control measures require an evidence-based understanding of their knowledge, attitudes, and practices (KAP) regarding malaria.
Luqman Samsudin, Muhammad Farhan Mohd Jaafar, Mohamad Khairul Anam Kamarulzaman, Noor Natasha Mohd Nor, Shafizah Ahmad Shafei, Nurul Ainaa Mohamad Shukor, Mohammed Rohaimie Abdul Rahman, Kumuthamalar Sangaran, Wan Rosmawati Wan Ismail, Jenn Zhueng Tam, Zulkarnain Md Idris   +10 more
openaire   +3 more sources