Results 111 to 120 of about 461,645 (274)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Achieving universal access and moving towards elimination of new HIV infections in Cambodia

Journal of the International AIDS Society, 2014
Introduction In the mid‐1990s, Cambodia faced one of the fastest growing HIV epidemics in Asia. For its achievement in reversing this trend, and achieving universal access to HIV treatment, the country received a United Nations millennium development ...
Mean Chhi Vun, Masami Fujita, Tung Rathavy, Mao Tang Eang, Seng Sopheap, Samreth Sovannarith, Chhea Chhorvann, Ly Vanthy, Oum Sopheap, Emily Welle, Laurent Ferradini, Chin Sedtha, Sok Bunna, Robert Verbruggen   +13 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Mandatory surveillance of bacteremia conducted by automated monitoring

Frontiers in Public Health
Except for a few countries, comprehensive all-cause surveillance for bacteremia is not part of mandatory routine public health surveillance. We argue that time has come to include automated surveillance for bacteremia in the national surveillance systems,
Kåre Mølbak, Kåre Mølbak, Christian Østergaard Andersen, Christian Østergaard Andersen, Ram B. Dessau, Ram B. Dessau, Ram B. Dessau, Svend Ellermann-Eriksen, Sophie Gubbels, Thøger Gorm Jensen, Jenny Dahl Knudsen, Brian Kristensen, Lisbeth Lützen, John Coia, Bente Ruth Scharvik Olesen, Mette Pinholt, Flemming Scheutz, Ute Wolff Sönksen, Kirstine K. Søgaard, Marianne Voldstedlund   +19 more
doaj   +1 more source

Corrigendum

Journal of the International AIDS Society, 2014
Introduction In the mid‐1990s, Cambodia faced one of the fastest growing HIV epidemics in Asia. For its achievement in reversing this trend, and achieving universal access to HIV treatment, the country received a United Nations millennium development ...
Mean Chhi Vun, Masami Fujita, Tung Rathavy, Mao Tang Eang, Seng Sopheap, Samreth Sovannarith, Chhea Chhorvann, Ly Vanthy, Oum Sopheap, Emily Welle, Laurent Ferradini, Chin Sedtha, Sok Bunna, Robert Verbruggen   +13 more
doaj   +1 more source

The cross-border mobility of companies within the European Community after the Cartesio ruling of the ECJ [PDF]

, 2009
This paper, in the field of European Company Law, analysis the current state of affairs concerning the cross-border mobility of companies within the European Community after the ECJ's Cartesio ruling, and indicates the potential impact of the latest case-
Cerioni, L
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Anthrax outbreak: exploring its biological agents and public health implications

Frontiers in Tropical Diseases
The (re)emergence of several infectious zoonoses underlines the need for the re-evaluation of the transmission patterns and key players responsible for effective inter-species transfer of diseases.
Seto C. Ogunleye, Mercy M. Olorunshola, Kolapo A. Fasina, Abdullahi T. Aborode, Olalekan C. Akinsulie, Abimbola Amoo, Boluwatife J. Olatoye, Akeem Bakare, Mariam A. Lawal, Oluwabori Adekanye, Ezemba C. Chinyere   +10 more
doaj   +1 more source

Pattern for malware remediation – A last line of defence tool against Malware in the global communication platform [PDF]

, 2012
Malware is becoming a major problem to every organization that operates on the global communication platform. The malicious software programs are advancing in sophistication in many ways in order to defeat harden deployed defenses. When an organization’s
Fung, C.C., Pan, J.Y.
core   +1 more source