Results 121 to 130 of about 202,953,608 (275)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

FLORI.CULTURAS SUBVERSIVAS Maniobras ecológicas desde el Sur re-existente

, 2017
El texto trata sobre la necesidad de abordar una crítica descolonial a la noción de naturaleza, tanto en su dimensión teórica como metodológica, pues ha sido claramente reificada por el conocimiento científico occidental para sostener desigualdades de ...
Romero Caballero, Belén
core   +12 more sources

Design and Establishment of an Integrated Safety and Preventive Maintenance System for Improving Safety Indexes

Salāmat-i kār-i Īrān, 2014
Design and Establishment of an Integrated Safety andPreventive Maintenance System for Improving Safety Indices   Background and aims: Accident analysis shows that one of the main reasons of accidents is non-integration of maintenance units with safety ...
I Mohammadfam, AA Shafikhani, AR Sultanian, F Mohammadfam   +3 more
doaj  

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Challenges that face the establishment of diabetes biobank in Jordan: a qualitative analysis of an online discussion forum

, 2019
Omar F Khabour,1 Ahmed Abu-Siniyeh1–31Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan; 2Department of Medical Laboratory Sciences, Faculty of Science, Al ...
Abu-Siniyeh A, Khabour OF
core  

Knowledge, attitude and practice levels regarding malaria among the Semai sub-ethnic indigenous Orang Asli communities in Pahang, Peninsular Malaysia: a stepping stone towards the prevention of human malaria re-establishment

Malaria Journal
In Malaysia, despite a decline in cases, malaria remains a major public health concern, especially among the vulnerable indigenous people (i.e. Orang Asli) in remote areas. Effective preventive and control measures require an evidence-based understanding of their knowledge, attitudes, and practices (KAP) regarding malaria.
Luqman Samsudin, Muhammad Farhan Mohd Jaafar, Mohamad Khairul Anam Kamarulzaman, Noor Natasha Mohd Nor, Shafizah Ahmad Shafei, Nurul Ainaa Mohamad Shukor, Mohammed Rohaimie Abdul Rahman, Kumuthamalar Sangaran, Wan Rosmawati Wan Ismail, Jenn Zhueng Tam, Zulkarnain Md Idris   +10 more
openaire   +3 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Compendium of HIV prevention interventions with evidence of effectiveness : from CDC's HIV/AIDS Prevention Research Synthesis Project [PDF]

Centers for Disease Control and Prevention, HIV/AIDS Prevention Research Synthesis Project. Compendium of HIV Prevention Interventions with Evidence of Effectiveness.
National Center for HIV, STD, and TB Prevention (U.S.) Divisions of HIV/AIDS Prevention-Intervention Research and Support.
core   +2 more sources

Genomic evolution and re-emergence of a multidrug-resistant Clostridioides difficile RT027 clone with reduced vancomycin susceptibility driving a prolonged hospital outbreak

Emerging Microbes and Infections
Following an extended period of declining prevalence of the epidemic Clostridioides difficile ribotype 027 (RT027) in Portugal, a genetically distinct, multidrug-resistant (MDR) RT027 strain with reduced susceptibility to vancomycin has emerged, causing ...
Joana Isidro, Filipa Dionísio, Frederico Alves, Soraia Almeida, Cláudia Santos, Manuel Mota Santos, Ernestina Reis, Júlio R Oliveira, João Paulo Gomes, Mónica Oleastro   +9 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source