Results 91 to 100 of about 116,131 (350)
RIP1-HAT1-SirT complex identification and targeting in treatment and prevention of cancer [PDF]
, 2018 Purpose: Alteration in cell death is a hallmark of cancer. A functional role regulating survival, apoptosis, and necroptosis has been attributed to RIP1/3 complexes.Experimental Design: We have investigated the role of RIP1 and the effects of MC2494 in ...
A. Baldi +23 more
core +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Comparative Sentencing Practice [PDF]
, 1958 Uppsalas befintliga konstmuseum i Uppsala Slott har små och opraktiska lokaler. Uppsala Konstmuseis Vänner har därför lobbyat mot kommunen för att bygga ett nytt museum.
Mannheim, Hermann
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Arrestees Substance Abuse: Moving Toward Rehabilitation Camps or Prisons
Iranian Rehabilitation Journal, 2020 Objectives: Illicit drug abuse and drug-related crimes are still a growing problem worldwide. Understanding the increasing number of individuals arrested for drug charges, as well as their characteristics is necessary to predict and establish preventive ...
Fahimeh Mohseni +3 more
doaj
European Approaches to Fighting Terrorism [PDF]
, 2010 På senare tid har smarta mobila enheter fått en allt större roll i vardagen och det finns en uppsjö av applikationer till dessa. Den som är uppmärksam kan upptäcka att prestandan och användarupplevelsen kan variera kraftigt mellan olika applikationer ...
Van Sliedregt, Elies
core +1 more source
The Preconditions for the Admission of the Preventive Measure Based on an European Arrest Warrant
, 2021 Denisa Barbu, Ana Maria Pana
openalex +2 more sources
Cardiac arrest: Treatment is prevention?
ResuscitationThe management of cardiac arrest has benefited from recent advances in cardiopulmonary resuscitation techniques. However, despite improvements, the incidence of sudden cardiac death is still high, with more than 4.1 deaths per 100,000 person-years in the United States, and continues to have very low survival rates at hospital discharge - 8% on average -
Descatha, Alexis, Savary, Dominique
openaire +3 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Rights of the Criminally Accused [PDF]
, 1990 För PLA-innehavare och key executives anser vi att beskattningen av carried interest ska ske i inkomstlaget kapital. Vi anser ej att den eventuella arbetsinsatsen utförd av PLA-innehavare har en sådan koppling till värdeökning i fonden att inkomstslaget ...
George, B. J., Jr.
core +2 more sources