Results 81 to 90 of about 36,512 (299)

Sulforaphane induces cell cycle arrest by protecting RB-E2F-1 complex in epithelial ovarian cancer cells

Molecular Cancer, 2010
Background Sulforaphane (SFN), an isothiocyanate phytochemical present predominantly in cruciferous vegetables such as brussels sprout and broccoli, is considered a promising chemo-preventive agent against cancer.
Morris Robert, Qazi Aamer M, Seward Shelly, Haider Mahdi, Pal Jagannath, Shah Jay, Chamala Sreedhar, Kumar Sanjeev, Bryant Christopher S, Semaan Assaad, Shammas Masood A, Steffes Christopher, Potti Ravindra B, Prasad Madhu, Weaver Donald W, Batchu Ramesh B   +15 more
doaj   +1 more source

Update on prevention and treatment of sudden cardiac arrest

Trends in Cardiovascular Medicine, 2019
Sudden cardiac arrest is the leading cause of cardiovascular mortality, posing a substantial public health burden. The incidence and epidemiology of sudden death are a function of age, with primary arrhythmia syndromes and inherited cardiomyopathies representing the predominant causes in younger patients, while coronary artery disease being the leading
Krokhaleva, Yuliya, Vaseghi, Marmar
openaire   +5 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Age, sex, and pre-arrest comorbidities shape the risk trajectory of sudden cardiac death- Patterns highlighted by population data in Taiwan [PDF]

[[abstract]]OBJECTIVES: Few reports have indicated the secular trend in the sudden cardiac death (SCD) incidence and pre-arrest comorbidities. This study aimed to comprehensively analyze the trend of SCD incidence and its association with pre-arrest ...
Sung, CW;Chang, HC;Fan, CY;Chen, CH;Huang, EP;Chen, L
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

House arrest vs. preventive detention: the labor and social consequences [PDF]

, 2017
Dissertação de mestrado em Direito Judiciário (área de especialização em Direitos Processuais e Organização Judiciária)As medidas de coação, ainda que fulcrais para a descoberta da verdade material e o restabelecimento da paz jurídica, colidem ...
Rodrigues, Joana Aguiar
core  

Korean Cardiac Arrest Research Consortium (KoCARC): rationale, development, and implementation [PDF]

, 2018
OBJECTIVE: This study aimed to describe the conceptualization, development, and implementation processes of the newly established Korean Cardiac Arrest Resuscitation Consortium (KoCARC) to improve out-of-hospital cardiac arrest (OHCA) outcomes. METHODS:
정성필
core   +4 more sources

Arrestees Substance Abuse: Moving Toward Rehabilitation Camps or Prisons

Iranian Rehabilitation Journal, 2020
Objectives: Illicit drug abuse and drug-related crimes are still a growing problem worldwide. Understanding the increasing number of individuals arrested for drug charges, as well as their characteristics is necessary to predict and establish preventive ...
Fahimeh Mohseni, Elie Moghimi Khorasani, Ali Asghar Nadi Ghara, Raheleh Rafaiee   +3 more
doaj  

Cardiac arrest: Treatment is prevention?

Resuscitation
The management of cardiac arrest has benefited from recent advances in cardiopulmonary resuscitation techniques. However, despite improvements, the incidence of sudden cardiac death is still high, with more than 4.1 deaths per 100,000 person-years in the United States, and continues to have very low survival rates at hospital discharge - 8% on average -
Descatha, Alexis, Savary, Dominique
openaire   +3 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source