Results 81 to 90 of about 610,493 (255)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Management Status of Myocarditis-Related Sudden Cardiac Death

Reviews in Cardiovascular Medicine
Myocarditis, a life-threatening disease that can result in cardiac arrest and sudden cardiac death, has garnered significant attention in recent years. This review provides a comprehensive overview of the management of myocarditis-related sudden cardiac ...
Ping Yan, Shujun Yang, Tong Wang
doaj   +1 more source

The effect of real-time CPR feedback and post event debriefing on patient and processes focused outcomes : a cohort study : trial protocol [PDF]

, 2011
Background: Cardiac arrest affects 30-35, 000 hospitalised patients in the UK every year. For these patients to be given the best chance of survival, high quality cardiopulmonary resuscitation (CPR) must be delivered, however the quality of CPR in real ...
Gao, F., Matthew W Cooke, Davies Robin P, Cooke, MW, Abella, B, Cooke, Matthew (Professor of clinical systems design), Ben Abella, Stallard, Nigel, Nigel Stallard, Stallard Nigel, Perkins, Gavin D., Stallard, N, Gao Smith, Fang; id_orcid, Fang Gao, Quinton, S, Davies, RP, Cooke Matthew W, Gao Fang, Woolley Sarah, Woolley, S, Gao, Fang, Davies, Robin P., Robin P Davies, Abella Ben, Sarah Woolley, Perkins, Gavin, Abella, Ben, Woolley, Sarah, Cooke, Matthew W, Sarah Quinton, Abella, Benjamin S., null null, Gavin D Perkins, Perkins, Gavin D, Smith, F. Gao (Fang Gao), Quinton Sarah, Davies, Robin P, Quinton, Sarah, Perkins Gavin D   +38 more
core   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

House arrest: competition with preventive measures applied by court decision

Известия высших учебных заведений. Поволжский регион: Общественные науки
Background. Improving legislation sometimes leads to results that were not orig-inally envisaged by the legislator. The addition of Article 108 of the Code of Criminal Pro-cedure to Part 1.1.
V.V. Geranin, S.N. Mal'tseva
doaj   +1 more source

The preventive effect of sodium-glucose co-transporter-2 inhibitors on life-threatening arrhythmias in patients with chronic kidney disease: a meta-analysis

Frontiers in Cardiovascular Medicine
BackgroundThe main cause of death for chronic kidney disease (CKD) is cardiac arrest caused by life-threatening arrhythmias, such as ventricular arrhythmia (VA) and atrioventricular block (AVB).
Qian Yang, Qian Yang, Yongjian Jia, Zhuodong Li, Yanmin Yu, Yi Dang, Yi Dang   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

TERMINATION OF PREVENTIVE MEASURES – COMPARATIVE LAW ISSUES [PDF]

Challenges of the Knowledge Society, 2017
Preventive measures are one of the most important institutions of the criminal procedural law, because of the fact that by taking it the freedom of the citizen is restricted - one of the most important constitutional rights.
Nadia CANTEMIR-STOICA
doaj