Results 41 to 50 of about 1,886,210 (293)

Régisseur d’œuvres : enjeux d’un métier émergent et perspectives de professionnalisation

open access: yesIn Situ, 2016
Curatorial functions, born with the modern museum’s emergence during the eighteenth century and in particular with the nascent concepts of inventorying and cataloguing collections, are organically linked to the figure of the person in charge of drawing ...
Sophie Daynes-Diallo   +2 more
doaj   +1 more source

Rethinking preventive conservation: Recent examples

open access: yes, 2022
The past few decades have seen an increasing awareness of the potential socioeconomical and environmental impact of investment in Cultural Heritage (CH). Preserving CH is not only an obligation to sustain and transmit it to the future generation but is also a driver of sustainable growth. Here, recently concluded projects are taken in consideration for
Lourenço, Paulo B.   +3 more
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Organiser les masses : le traitement des archives photographiques du journal L’Humanité

open access: yesIn Situ, 2018
The photo collection of the newspaper L’Humanité, published by the French communist party, was deposited at the departmental archives of Seine-Saint-Denis in 2003. It comprises more than two million pictures.
Joël Clesse, Maxime Courban
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

SIMULATION OF PREVENTIVE CONSERVATION IN A MUSEUM BUILDING - Deliverable D6.3

open access: yes, 2023
This deliverable reports on the work carried out in Task 6.3 of WP6 (Simulation of preventive conservation in a museum building), which concerns microclimate control, simulated for a hangar selected in D6.1, designed for preventive conservation of ...
Fiser Jaromir
core   +1 more source

Conservation in Kansas

open access: yes, 2008
Report covers Fiscal Year 2007 and 2008, with planned activities listed for Fiscal Year 2009.<br>Continues title: Soil conservation in Kansas which previously was continued by: Conservation in ...
Kansas. State Conservation Commission
core   +1 more source

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