Results 51 to 60 of about 125,549 (303)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The complexities of managing historic buildings with BIM [PDF]

, 2020
Purpose The adoption of building information modelling (BIM) in managing built heritage is an exciting prospect, but one that presents complexities additional to those of modern buildings.
Charlton, James, Greenwood, David, Kelly, Kenneth, Moreton, Leo   +3 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Museum reproduction of metallic archaeological artefacts: from lost wax casting techniques to artificial metals

Ge-conservación, 2017
Reproductions of archaeological artefacts play a necessary role in our societies while allowing an induced multiplicity of the original, which supposes benefits for conservation, dissemination and promotion of our heritage.
Miquel Angel Herrero-Cortell, Xavier Mas-Barberà, Carmen Marcos Martínez, Montserrat Lastras Pérez, Mario Culebras Rubio   +4 more
doaj   +1 more source

A Smart Archive Box for Museum Artifact Monitoring Using Battery-Less Temperature and Humidity Sensing

Sensors, 2021
For the first time, this paper reports a smart museum archive box that features a fully integrated wireless powered temperature and humidity sensor. The smart archive box has been specifically developed for microclimate environmental monitoring of stored
Dinesh R. Gawade, Steffen Ziemann, Sanjeev Kumar, Daniela Iacopino, Marco Belcastro, Davide Alfieri, Katharina Schuhmann, Manfred Anders, Melusine Pigeon, John Barton, Brendan O’Flynn, John L. Buckley   +11 more
doaj   +1 more source

Patterns and correlates of claims for brown bear damage on a continental scale [PDF]

, 2017
Wildlife damage to human property threatens human-wildlife coexistence. Conflicts arising from wildlife damage in intensively managed landscapes often undermine conservation efforts, making damage mitigation and compensation of special concern for ...
Agnieszka, Olszańska, Aleksandar, Dutsov, Alexandros A., Karamanlidis, Anne K., Scharf, Carlos, Bautista, Ciucci, Paolo, Claudio, Groff, Djuro, Huber, Eloy, Revilla, Janis, Ozolins, Javier, Naves, Juan, Seijas, Jörg, Albrecht, Klemen, Jerina, Marko, Jonozovič, Maryna, Shkvyria, Michal, Adamec, Néstor, Fernández, Pierre Ives, Quenette, Raido, Kont, Robin, Rigg, Santiago, Palazón, Selva, Nuria   +22 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Management of hypertension at the community level in Sub-Saharan Africa (SSA): towards a rational use of available resources [PDF]

, 2011
Hypertension is emerging in many developing nations as a leading cause of cardiovascular mortality, morbidity and disability in adults. In sub-Saharan African (SSA) countries it has specificities such as occurring in young and active adults, resulting in
Twagirumukiza, Marc, Van Bortel, Lucas
core   +2 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source