Results 81 to 90 of about 1,116,439 (297)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Iranian Journal of Public Health, 1978 The control of cigarette smoking can do more to improve health and prolong life than any other single action in the whole field of preventive medicine. Many smokers desire to stop but need instructions and support.
Sh.Ahangari
doaj
The broiler meat system in Nairobi, Kenya: using a value chain framework to understand animal and product flows, governance and sanitary risks [PDF]
, 2017 Livestock food systems play key subsistence and income generation roles in low to middle income countries and are important networks for zoonotic disease transmission.
AfDB +39 more
core +2 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Tidsskrift for Samfunnsforskning, 2010 Forebygging, hverdagsliv og samfunnsendring. Hvordan forebyggende medisin blir en del av folks hverdagsliv Denne artikkelen ser på hvordan folk forholder seg til forebygging av sykdom over tid.
Jorid Anderssen
doaj +1 more source
Optimality of no-fault medical liability systems [PDF]
This paper considers a model of defensive medicine where doctors are imperfect agents of insured patients. A national insurer subsidises both curative and preventive medical care consumed by risk averse patients.
Kao, Tina, Vaithianathan, Rhema
core
Health and medicine in the Islamic tradition based on the book of Medicine (kitab al-tibb) of Sahih al- Bukhari [PDF]
, 2006 This article attempts to study the book of medicine (kitab al-tibb) in Sahih al-Bukhari. The book of medicine appears in the book 76 which consists of 58 chapters with 105 traditions (hadiths).
Deuraseh, Nurdeng@Nurdeen
core
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Realizing Health Reform's Potential: How the Affordable Care Act Will Strengthen Primary Care and Benefit Patients, Providers, and Payers [PDF]
, 2011 Examines issues in primary care and outlines the 2010 healthcare reform law's provisions to strengthen it, including temporary hikes in Medicare and Medicaid payments and support for innovations in care delivery and primary care workforce ...
Georgette Lawlor +3 more
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