Results 141 to 150 of about 7,712,805 (262)

Mind–Body Interventions for Prediabetes Management: Traditional Chinese Exercise and Its Dual Effects on Metabolic Control and Psychological Well-Being—A Systematic Review and Meta-Analysis

Journal of Diabetes Research
Yaoming Yang, Ran Chen, Xinbao Wang, Yuqian Yan, Tao Huang, Chunfang Wang, Guoyong Yu   +6 more
doaj   +1 more source

Embracing Tuberculosis Preventive Treatment: A Crucial Step towards TB Control in Pakistan. [PDF]

Pak J Med Sci
Basit A, Hamayun Z.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Predicted choice and acceptability of regimens for tuberculosis preventive treatment among people living with HIV in Uganda - A discrete choice experiment. [PDF]

PLOS Glob Public Health
Aschmann HE, Musinguzi A, Kadota JL, Namale C, Kakeeto J, Nakimuli J, Akello L, Welishe F, Nakitende A, Berger C, Dowdy DW, Cattamanchi A, Semitala FC, Kerkhoff AD.   +13 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Real-world short-term effectiveness of erenumab after single versus multiple prior preventive treatment failures. [PDF]

BMC Neurol
Schmidt C, Becker L, Lindner D, Kleinschnitz C, Becker AW, Holle D, Scheffler A.   +6 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Preliminary research on the role of ferroptosis in insomnia

Asian Journal of Surgery
Xiaona Ye, Wenjing Wang, Yafeng Zheng, Xingjun Han   +3 more
doaj   +1 more source

Lessons learned from implementing a large-scale contact investigation and TB preventive treatment project in India. [PDF]

IJTLD Open
Kalottee B, Nuken A, Kalra A, Chadha SS, Mannan S, Singh M, Solanki H, Taralekar R, Yassin M, Restrepo N, Rao R, Mattoo SK, Dhawan V, Rajan S.   +13 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source