Results 161 to 170 of about 7,712,805 (262)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Understanding Barriers to Uptake of TB Preventive Treatment Among People Living with HIV in Zimbabwe: A Qualitative Assessment of Healthcare Workers' Perspectives. [PDF]

Trop Med Infect Dis
Mapuranga T, Timire C, Ncube RT, Dube S, Mlilo N, Chiteve C, Mugurungi O, Mutasa-Apollo T, Kavenga F, Gwanzura C, Ncube M, Siziba N, Berger SD, Maphosa T, Charles M, Dlodlo RA, Ershova J.   +16 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Brain-Derived Neurotrophic Factor (BDNF) in the gut-brain axis: Mechanisms in preventing and treating insomnia and insights from traditional Chinese medicine

Asian Journal of Surgery
Chao Sun, Hongyu Song, Yingying Zhao, Xiaona Ye   +3 more
doaj   +1 more source

The epidemiological impact, costs, and cost-effectiveness of implementing household contact investigation with tuberculosis preventive treatment in Nepal: a model-based analysis. [PDF]

BMC Glob Public Health
Paudel R, Thapa A, Shrestha S, Dorjee K, Dhital R, Dowdy DW, Caws M, Shrestha S.   +7 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Swallowing-related cough and health status of old adults: Results from a nationwide cross-sectional study

Chinese Medical Journal
Huai-Yu Wang, Minghua Bai, Jinwei Wang, Zhuqing Li, Ji Wang, Qi Wang, Xiangxiang Pan   +6 more
doaj   +1 more source

Progression to active TB post-TB preventive treatment among household contacts in India: Axshya Plus project (2021-2024). [PDF]

IJTLD Open
Kalottee B, Nuken A, Dubey A, Mahajan P, Solanki H, Taralekar R, Yassin M, Restrepo N, Rao R, Mattoo SK, Dhawan V, Rajan S.   +11 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Scaling Up Tuberculosis Preventive Treatment: Progress and Factors Influencing Optimization - China, 2022-2025. [PDF]

China CDC Wkly
Xu C, Li J, Wen Y, Hu D, Yu R, Zhao Y.
europepmc   +1 more source