Results 91 to 100 of about 739,700 (305)

Boldness and natural behaviors in the African lion (Panthera leo): How are they related? [PDF]

, 2017
The African lion (Panthera leo) population is diminishing rapidly, approximately 43% since 1993 (Bauer et al., 2016. The species is currently listed as vulnerable by the IUCN (Bauer et al., 2016).
Kamyk, Courtney M
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Competition and Facilitation Influence Central Place Foraging Ecology in a Colonial Marine Predator

Ecology and Evolution
Coloniality is strongly shaped by aspects of social foraging behaviour. For example, colonies may be important sources of information, while food competition may increase foraging efforts and limit colony size.
Liam P. Langley, Sam L. Cox, Samantha C. Patrick, Stephen C. Votier   +3 more
doaj   +1 more source

Mosquito feeding affects larval behaviour and development in a moth.

PLoS ONE, 2011
Organisms are attacked by different natural enemies present in their habitat. While enemies such as parasitoids and predators will kill their hosts/preys when they successfully attack them, enemies such as micropredators will not entirely consume their ...
Véronique Martel, Fredrik Schlyter, Rickard Ignell, Bill S Hansson, Peter Anderson   +4 more
doaj   +1 more source

Mass mortalities in bivalve populations: A review of the edible cockle Cerastoderma edule (L.) [PDF]

, 2014
Mass mortalities in bivalve populations have long been of particular concern, especially when the species supports a commercial fishery or is of conservation interest.
Burdon, Daryl, Callaway, Ruth, Elliott, Michael, Smith, Tim, Wither, Andrew   +4 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Stability and bifurcation analysis of a discrete Leslie predator-prey system via piecewise constant argument method

AIMS Mathematics
The objective of this study was to analyze the complex dynamics of a discrete-time predator-prey system by using the piecewise constant argument technique. The existence and stability of fixed points were examined.
Saud Fahad Aldosary, Rizwan Ahmed
doaj   +1 more source

Patchy zooplankton grazing and high energy conversion efficiency: Ecological implications of sandeel behavior and strategy [PDF]

, 2013
Sandeel display strong site-fidelity, and spend most of their life buried in the seabed. This strategy carries important ecological implications. Sandeels save energy when they are not foraging but in return are unable to move substantially and therefore
Mikael van Deurs, Asbjørn Christensen, Anna Rindorf
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source