Results 61 to 70 of about 508 (164)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Selective consumption of sacoglossan sea slugs (Mollusca: Gastropoda) by scleractinian corals (Cnidaria: Anthozoa).

PLoS ONE, 2019
Recent studies revealed that reef corals can eat large-sized pelagic and benthic animals in addition to small planktonic prey. As follow-up, we document natural ingestion of sea slugs by corals and investigate the role of sacoglossan sea slugs as ...
Rahul Mehrotra, Coline Monchanin, Chad M Scott, Niphon Phongsuwan, Manuel Caballer Gutierrez, Suchana Chavanich, Bert W Hoeksema   +6 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Characterizing a novel predator–prey relationship between native Diplonychus esakii (Heteroptera: Belostomatidae) and invasive Gambusia affinis (Teleostei: Poeciliidae) in central China

International Aquatic Research, 2017
A considerable body of the literature considers the potential impact of exotic predators on native prey organisms, while comparatively, few studies have asked whether and how native predators include novel prey types into their diet spectrum.
Xu Ouyang, Jiancao Gao, Bojian Chen, Zaizhao Wang, Hong Ji, Martin Plath   +5 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Use of fluorescent microspheres to identify larval live food preferences of yellow domino damselfish (Dascyllus auripinnis), spinecheek clownfish (Amphiprion biaculeatus) and pigfish (Orthopristis chrysoptera)

Aquaculture Reports
Successful aquaculture of marine fish is reliant on feeding live food organisms to small larvae while maximizing survival. Currently most larvae are fed live rotifers and Artemia nauplii, and occasionally copepod nauplii.
Jonathan Simon, Cortney L. Ohs
doaj   +1 more source

Prey Acceptability and Preference of Oenopia conglobata (Coleoptera: Coccinellidae), a Candidate for Biological Control in Urban Green Areas

Insects, 2018
Oenopia conglobata is one of the most common ladybird species in urban green areas of the Mediterranean region. We have obtained data about its prey acceptability and prey preferences.
Belén Lumbierres, Filipe Madeira, Xavier Pons   +2 more
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Wild Seasons, Urban Stasis: Anthropogenic Food Subsidies Buffer Seasonal Dietary Shifts for Coyotes (Canis latrans) in a Wildland‐Urban Landscape South of Mexico City

Ecology and Evolution
Coyote (Canis latrans) populations are expanding into urban areas, yet how their feeding ecology adapts to the wildland–urban interface remains poorly understood, particularly near megacities such as Mexico City.
Andrés Arias‐Alzate, Nitzia Flores‐Raíz, Juan F. Acevedo‐Quintero, José F. González‐Maya, Heliot Zarza   +4 more
doaj   +1 more source