Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
Online Auction Design Using Distribution-Free Uncertainty Quantification with Applications to E-Commerce. [PDF]
Han J, Dai X.
europepmc +1 more source
Spatiotemporal Clustering of Key Food Commodity Prices Using Multivariate Time Series
Dhiya Ulayya Tsabitah +2 more
openalex +2 more sources
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Correction: Financing the introduction of new vaccines to the national immunisation programme in China: challenges and options for action. [PDF]
europepmc +1 more source
Consequences of Canada's Drug Agency Reimbursement Recommendations for New Medicines and Pan-Canadian Pharmaceutical Alliance Price Negotiations on Patient Access. [PDF]
Rawson NSB.
europepmc +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Stock price dynamics prediction based on multi-scale fractals and deep learning. [PDF]
Du Y, Tian Y.
europepmc +1 more source
Health Care Price Transparency : Opportunities to Lower Costs and Improve Competition ADDENDUM
Christopher M. Whaley
openalex +1 more source

