Results 71 to 80 of about 550,112 (248)
SensorsCerebral blood volume (CBV) is an essential metric that indicates and evaluates various healthy and pathologic conditions. Most methods of CBV measurement are cumbersome and have a poor temporal resolution. Recently, it has been proposed that signals and
Noah Silvaggio +8 more
doaj +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Data in Brief, 2019 This Data in Brief article presents sedimentological and geochemical parameters from a set of sedimentary samples collected in the Saint-Charles River, a tributary of the Saint-Lawrence River flowing in Québec City (QC, Canada).
Léo Chassiot +5 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
A randomized trial looking at planning prompts to reduce opioid prescribing
Nature CommunicationsPrior work has demonstrated that personalized letters are effective at reducing opioid and benzodiazepine prescribing, but it is unclear whether If/when-then planning prompts would enhance this effect.
Jason N. Doctor +5 more
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AerospaceThe Arctic region is known for its harsh and remote environment. Some of the significant system problems in that region include solving communication issues and building a high-capacity terrestrial infrastructure.
Anastasiya Yermolenko, Philip Ferguson
doaj +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
InfrastructuresFatigue is one of the main sources of mechanical failure in steel bridges. However, a few studies have investigated the relationship between the longitudinal shape of bridge girders and long-term fatigue effects.
Graziano Fiorillo, Navid Manouchehri
doaj +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source