Results 31 to 40 of about 341,402 (293)

L1-determined ideals in group algebras of exponential Lie groups

open access: yes, 2012
A locally compact group $G$ is said to be $\ast$-regular if the natural map $\Psi:\Prim C^\ast(G)\to\Prim_{\ast} L^1(G)$ is a homeomorphism with respect to the Jacobson topologies on the primitive ideal spaces $\Prim C^\ast(G)$ and $\Prim_{\ast} L^1(G)$.
Boidol J.   +11 more
core   +1 more source

Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C

open access: yesNature Communications, 2020
Mycobacteria Prim-PolC performs short gap synthesis following removal of lesions during excision repair. Here the authors resolve crystal structures of pre- and post-catalytic Prim-PolC complexes bound to gapped DNA substrates to define its mechanism.
Nigel C. Brissett   +7 more
doaj   +1 more source

MEMBANGUN POHON MERENTANG MINIMUM DENGAN MENGGUNAKAN ALGORITMA PRIM [PDF]

open access: yes, 2009
Graph is the method of discrete problem solution searching that was in the real world. Graph has much of concepts. The ones is Tree concept. Tree concept is being the significant and the popular concept because support to applies graph for a lot of ...
SUSIANI, ERNA
core  

J-PRiM: a Java tool for a process reengineering i* methodology [PDF]

open access: yes, 2006
The i* approach is a consolidated modelling technique that has proven to be useful in the requirements engineering phases of software development. Using i* requires the adoption of a methodology for defining the models and tool support for manipulating ...
Franch Gutiérrez, Javier   +2 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Galdós y la muerte de Prim: entre los «Episodios Nacionales» y el cine

open access: yesCuadernos para la Investigación de la Literatura Hispánica, 2022
Un siglo después del fallecimiento de Benito Pérez Galdós, su obra continúa siendo de obligada lectura para todo aquel interesado en el siglo xix español.
Diego Cameno Mayo
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

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